Langerhans cell histiocytosis laboratory tests

	Langerhans cell histiocytosis Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Langerhans cell histiocytosis from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
Chest X Ray
CT
MRI
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Langerhans cell histiocytosis laboratory tests On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Langerhans cell histiocytosis laboratory tests All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Langerhans cell histiocytosis laboratory tests
on Langerhans cell histiocytosis laboratory tests
Langerhans cell histiocytosis laboratory tests in the news
Blogs on Langerhans cell histiocytosis laboratory tests
Directions to Hospitals Treating Langerhans cell histiocytosis
Risk calculators and risk factors for Langerhans cell histiocytosis laboratory tests

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Laboratory findings consistent with the diagnosis of Langerhans cell histiocytosis include abnormal complete blood count, erythrocyte sedimentation rate (ESR), basic metabolic panel, and immunohistochemistry.^[1]^[2]^[3]^[4]

The following lab abnormalities may be seen on basal metabolic panel:^[5]^[6]

Low urine specific gravity (1.008)
Low specific gravity persisted during a water deprivation test
Urine osmolality and urine specific gravity normalize following desmopressin administration

↑ DiCaprio MR, Roberts TT (2014). "Diagnosis and Management of Langerhans Cell Histiocytosis". J Am Acad Orthop Surg. 22 (10): 643–652. doi:10.5435/JAAOS-22-10-643. PMID 25281259.
↑ Langerhans cell histiocytosis. Wikipedia (2015) https://en.wikipedia.org/wiki/Langerhans_cell_histiocytosis Accessed on February, 2 2016
↑ Langerhans cell histiocytosis. Radiopeadia (2015) http://radiopaedia.org/articles/langerhans-cell-histiocytosis Accessed on February, 3 2016
↑ Langerhans Cell Histiocytosis Treatment (PDQ®): Health Professional Version. National Cancer Institute (2015) http://www.cancer.gov/types/langerhans/hp/langerhans-treatment-pdq Accessed on February, 3 2016
↑ Montefusco L, Harari S, Elia D, Rossi A, Specchia C, Torre O, Adda G, Arosio M (May 2018). "Endocrine and metabolic assessment in adults with Langerhans cell histiocytosis". Eur. J. Intern. Med. 51: 61–67. doi:10.1016/j.ejim.2017.11.011. PMID 29198444.
↑ Liu DG, Zhang YX, Li F (February 2012). "Multisystem Langerhans cell histiocytosis with liver dysfunction as the first presentation: A case report". Oncol Lett. 3 (2): 391–394. doi:10.3892/ol.2011.462. PMID 22740918.