Neurofibroma laboratory findings
|
Neurofibroma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Neurofibroma laboratory findings On the Web |
|
American Roentgen Ray Society Images of Neurofibroma laboratory findings |
|
Risk calculators and risk factors for Neurofibroma laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]
Overview
Immunohistochemistry of neurofibroma shows positivity for S100, CD34, and factor XIIIa and negativity for EMA (except in plexiform neurofibromas).
Laboratory Findings
Immunohistochemistry of neurofibroma is as follows:
- Positive for:
- Negative for:
- EMA (except in plexiform neurofibromas)
- Keratin
- Smooth muscle actin
- Desmin
- Calponin
- Caldesmon
- p53
| Immunohistochemical stain | Neurofibroma | Schwannoma |
|---|---|---|
| S-100 and Sox10 | Moderate positivity | Strong, diffuse positivity |
| CD34 | Moderate | Scattered cells in Antoni B areas |
| Neurofilament (and Bielshowsky) | Stains entrapped axons within lesion | Stains peripherally located axons of parent nerve |
| Factor XIIIa | Moderate | Negative to focal |
| Calretinin | Negative to focal | Moderate |
| GFAP | Variable, weak | Variable, moderate |