Osteosarcoma classification

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Overview

Osteosarcoma may be classified according to the World Health Organization’s histologic classification of bone tumors into three groups: central (medullary) tumors, surface (peripheral) tumors, and extraskeletal tumors.

Classification

Osteosarcoma may be classified according to the World Health Organization’s histologic classification of bone tumors into three groups:

Central (medullary) tumors:

• Conventional central osteosarcomas.
• Telangiectatic osteosarcomas.
• Intraosseous well-differentiated (low-grade) osteosarcomas.
• Small-cell osteosarcomas.

Surface (peripheral) tumors:

• Parosteal (juxtacortical) well-differentiated (low-grade) osteosarcomas.
• Periosteal osteosarcoma: Low-grade to intermediate-grade osteosarcomas.
• High-grade surface osteosarcomas.

Extraskeletal:

• Extraskeletal osteosarcomas.