Osteosarcoma classification
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Osteosarcoma classification On the Web |
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Risk calculators and risk factors for Osteosarcoma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammadmain Rezazadehsaatlou[2].
Overview
Osteosarcoma (OS) is a rare bone cancer which affects both adolescents and young adults. Osteosarcoma was classified as primary and secondary. Later the the World Health Organization sub-typed as intramedullry/central and surface osteosarcoma with a number of sub-types under each grou
Classification [1][2][3][3][4]
| Primary osteosarcoma | Conventional-intramedullary/central high grade (most common) further sub-typed as: | Osteoblastic (50%)
Chondroblastic (25%) Fibroblastic (25%) |
| Secondary osteosracomas | Unusual forms of osteosarcoma given below are viewed as subtypes of conventional osteosarcoma because their biological behavior is similar. | Osteoblastic osteosarcoma-sclerosing type
Osteosarcoma resembling osteoblastoma Chondromyxoid fibroma‑like osteosarcoma Chondroblastoma-like osteosarcoma Clear-cell osteosarcoma Malignant fibrous histiocytoma‑like osteosarcoma Giant cell rich osteosarcoma Epithelioid osteosarcoma |
| subtypes | Osteosarcoma |
|---|---|
| CENTRAL (MEDULLARY) | a. Conventional high-grade central osteosarcoma (80%)
b. Telangiectatic osteosarcoma (4%) c. Intraosseous well-differentiated (low-grade) osteosarcoma (1-2%) d. Small cell osteosarcoma (1-2%) |
| SURFACE (PERIPHERAL) | a. Parosteal (juxtacortical) well-differentiated (low-grade) osteosarcoma (4-6%)
b. Periosteal osteosarcoma - low- to intermediate-grade osteosarcoma (<4%) c. High-grade surface osteosarcoma (1%) |
References
- ↑ Bielack SS, Hecker-Nolting S, Blattmann C, Kager L (2016). "Advances in the management of osteosarcoma". F1000Res. 5: 2767. doi:10.12688/f1000research.9465.1. PMC 5130082. PMID 27990273.
- ↑ Kundu ZS (May 2014). "Classification, imaging, biopsy and staging of osteosarcoma". Indian J Orthop. 48 (3): 238–46. doi:10.4103/0019-5413.132491. PMC 4052020. PMID 24932027.
- ↑ 3.0 3.1 Misaghi A, Goldin A, Awad M, Kulidjian AA (2018). "Osteosarcoma: a comprehensive review". SICOT J. 4: 12. doi:10.1051/sicotj/2017028. PMC 5890448. PMID 29629690.
- ↑ Ozaki T, Flege S, Liljenqvist U, Hillmann A, Delling G, Salzer-Kuntschik M, Jürgens H, Kotz R, Winkelmann W, Bielack SS (February 2002). "Osteosarcoma of the spine: experience of the Cooperative Osteosarcoma Study Group". Cancer. 94 (4): 1069–77. PMID 11920477.