Carcinoma of the penis historical perspective
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Overview
Historical Perspective
History of Circumcision
- The earliest reference to the circumcision procedure dates back to around 2400 B.C, in Egypt
- In the late 1800s, doctors turned to circumcision to "cure" an array of ailments, from childhood fevers to brass poisoning to paralysis
- Lewis Sayre, a professor of orthopedic surgery at Bellevue Hospital Medical College,was called to the bedside of a 5-year-old boy whose knees were flexed and paralyzed, preventing him from walking
- During his examination, Sayre discovered that the boy's foreskin had contracted, causing the child great pain
- Speculating that the foreskin problem could be the source of the boy's "physical prostration and nervous exhaustion," Sayre conducted a circumcision the next day
- In less than two weeks, Sayre reported, the boy was walking again
History of HPV relation to Carcinoma of Penis
- In 1965, the first published HPV study characterized its DNA
- Prior to 1965, papillomavirus studies focused on rabbit papillomavirus and its association to cancer
- During the 1970’s, more than one type of HPV was recognized
- In 1982, several studies associating HPV type 6 with genital warts, but neither cervical nor penile cancer, were published
- The theory that penile and cervical cancer may have a common etiology was proposed as early as 35 years ago
- Initial studies supported a causal relationship between male sexual behaviors and the incidence of cervical carcinoma before the role of HPV was even recognized