Osteosarcoma causes
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammadmain Rezazadehsaatlou[2].
|
Osteosarcoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Osteosarcoma causes On the Web |
|
American Roentgen Ray Society Images of Osteosarcoma causes |
Overview
There are no established exact causes for osteosarcoma. But physicians and medical researchers suggest that the the DNA mutations (either inherited or acquired after birth) inside the bone cellular system can be responsible for the occurrence of OS.
Causes
There is limited understanding about the exact aetiology of osteosarcoma. However, a number of risk factors have been identified in this regard and please refer to the risk factor section of this chapter.
The peak age during the puberty seems to have an important relationship between rapid bone growth and the development and progression of OS. Commonly OS occur at an earlier age in girls than boys. OS have also been associated with the previous history of radiation, the use of diagnostic radiocontrast agent s such as: intravenous radium 224 and Thorotrast, and also the exposure to alkylating agents.
On the other hand, the conditions associated with an increased risk of development of osteosarcoma include: Paget’s disease, solitary or multiple osteochondroma, solitary enchondroma or enchondromatosis (Ollier’s disease), multiple hereditary exostoses, fibrous dysplasia, chronic osteomyelitis, sites of bone infractions and sites of metallic implants.Moreover, the hereditary disorders have been correlated with the development of OS which were fully discussed in the pathophysiology section.