Carotid body tumor natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]
Overview
If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
OR
Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
OR
Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
Natural History, Complications, and Prognosis
Natural History
- The symptoms of carotid body tumor usually develop in the fifth decade of life and start with symptoms such as asymptomatic mass in the anterior triangle of the neck.[1]
- In familial cases, it tends to manifest at a younger age.[2]
- This tumor is a slowly growing mass with the median growth rate of 1.0mm/year.
- The median time needed for the tumor to be doubled is 4.2 years.[2]
- If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
Complications
- Carotid body tumor may result in neurovascular complications peri and post operatively.[3][4]
- These complications include cranial nerve damage as well as carotid vessel involvement.
- Neurovascular complication rate differs according to the Shamblin subtype.
- For type I and II, the peri and post-surgical complications are low and around 0% to 3% of the cases.
- For Type III, it may be as high as 7% to 35% of the cases.
Prognosis
- Prognosis is generally good after complete surgical removal of the tumor.[5]
- In case of malignant metastasis, the follow-up must be done continuously, however, recurrence or metastasis may occur years later.
- The 10-year survival rate of patients with malignant paraganglioma is approximately 50%.
- Depending on the extent of the [tumor/disease progression] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
- The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
- [Subtype of disease/malignancy] is associated with the most favorable prognosis.
- The prognosis varies with the [characteristic] of the tumor; [subtype of disease/malignancy] have the most favorable prognosis
References
- ↑ Lee, Ki Yeol; Oh, Yu-Whan; Noh, Hyung Jun; Lee, Yu Jin; Yong, Hwan-Seok; Kang, Eun-Young; Kim, Kyeong Ah; Lee, Nam Joon (2006). "Extraadrenal Paragangliomas of the Body: Imaging Features". American Journal of Roentgenology. 187 (2): 492–504. doi:10.2214/AJR.05.0370. ISSN 0361-803X.
- ↑ 2.0 2.1 Burgess, Alfred; Calderon, Moises; Jafif-Cojab, Marcos; Jorge, Diego; Balanza, Ricardo (2017). "Bilateral carotid body tumor resection in a female patient". International Journal of Surgery Case Reports. 41: 387–391. doi:10.1016/j.ijscr.2017.11.019. ISSN 2210-2612.
- ↑ Lim JY, Kim J, Kim SH, Lee S, Lim YC, Kim JW, Choi EC (June 2010). "Surgical treatment of carotid body paragangliomas: outcomes and complications according to the shamblin classification". Clin Exp Otorhinolaryngol. 3 (2): 91–5. doi:10.3342/ceo.2010.3.2.91. PMC 2896739. PMID 20607078.
- ↑ Plukker JT, Brongers EP, Vermey A, Krikke A, van den Dungen JJ (October 2001). "Outcome of surgical treatment for carotid body paraganglioma". Br J Surg. 88 (10): 1382–6. doi:10.1046/j.0007-1323.2001.01878.x. PMID 11578296.
- ↑ Wieneke, Jacqueline A.; Smith, Alice (2009). "Paraganglioma: Carotid Body Tumor". Head and Neck Pathology. 3 (4): 303–306. doi:10.1007/s12105-009-0130-5. ISSN 1936-055X.