Osteosarcoma risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammadmain Rezazadehsaatlou[2].
Overview
Common risk factors in the development of osteosarcoma are radiation to bones, alkylating antineoplastic agents, Paget disease, multiple hereditary osteochondromas, fibrous dysplasia, Bloom syndrome,Rothmund-Thomson syndrome, and Li-Fraumeni syndrome.
Risk Factors
The most common risk factors for osteosarcoma include:
- Teenage growth spurts
- Being tall
- Previous treatment with radiation for another cancer, especially at a young age or with high doses of radiation
- Drugs: past treatment with anticancer drugs called alkylating antineoplastic agents
- Presence of certain benign (noncancerous) bone diseases, such as:
- Paget disease of bone
- Multiple hereditary osteochondromas
- Fibrous dysplasia
- Enchondromtosis
- Presence of certain rare, inherited disorders, such as:
- Bloom syndrome
- Diamond-Blackfan anemia
- Familial adenomatous polyposis
- Li-Fraumeni syndrome
- Hereditary retinoblastoma
- Rothmund-Thomson syndrome
- Werner syndrome