Waldenström's macroglobulinemia classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2], Roukoz A. Karam, M.D.[3]; Grammar Reviewer: Natalie Harpenau, B.S.[4]
Overview
There is no established system for the classification of Waldenström's macroglobulinemia. However, according to a devised criteria based upon patient's symptoms, it can be classified into symptomatic and asymptomatic Waldenstrom macroglobulinemia.
Classification
There is no established system for the classification of Waldenström's macroglobulinemia. However, according to a devised criteria based upon patient's symptoms, it can be classified into:[1]
- Symptomatic Waldenstrom macroglobulinemia.
- Asymptomatic/Smoldering Waldenstrom macroglobulinemia (SWM).[2]
Criteria | Symptomatic WM | Asymptomatic WM | IgM-Related Disorders | MGUS |
---|---|---|---|---|
IgM monoclonal protein | + | + | + | + |
Bone marrow infiltration | + | + | - | - |
Symptoms attributable to IgM | + | - | + | - |
Symptoms attributable to tumor infiltration | + | - | - | - |
References
- ↑ Dimopoulos MA, Kyle RA, Anagnostopoulos A, Treon SP (2005). "Diagnosis and management of Waldenstrom's macroglobulinemia". J Clin Oncol. 23 (7): 1564–77. doi:10.1200/JCO.2005.03.144. PMID 15735132.
- ↑ Kyle RA, Treon SP, Alexanian R, Barlogie B, Björkholm M, Dhodapkar M; et al. (2003). "Prognostic markers and criteria to initiate therapy in Waldenstrom's macroglobulinemia: consensus panel recommendations from the Second International Workshop on Waldenstrom's Macroglobulinemia". Semin Oncol. 30 (2): 116–20. doi:10.1053/sonc.2003.50038. PMID 12720119.