Acute lymphoblastic leukemia history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Carlos A Lopez, M.D. [3]

Overview

Symptoms of acute lymphoblastic leukemia include generalized weakness and fatigue, frequent or unexplained fever and infections, weight loss and/or loss of appetite, excessive bruising, bleeding from wounds, nosebleeds, petechiae, bone pain, joint pains and dyspnea.

History

Patients with acute lymphoblastic leukemia may have a positive history of:

Symptoms

Common symptoms

Common symptoms of acute lymphoblastic leukemia include the following:^[1]^[2]^[3]^[4]^[5]

Generalized weakness and fatigue
Anemia
Frequent or unexplained fever and infections
Weight loss
Anorexia
Excessive bleeding from minor wounds
Bone pain
Dyspnea
Excessive bruising
Petechiae

Less common symptoms

Epistaxis^[6]
Arthralgia (caused by the spread of "blast" cells to the surface of the bone or into the joint from the marrow cavity)^[7]

References

↑ Clarke RT, Van den Bruel A, Bankhead C, Mitchell CD, Phillips B, Thompson MJ (October 2016). "Clinical presentation of childhood leukaemia: a systematic review and meta-analysis". Arch. Dis. Child. 101 (10): 894–901. doi:10.1136/archdischild-2016-311251. PMID 27647842.
↑ Vesterby A, Myhre Jensen O (September 1985). "Aseptic bone/bone marrow necrosis in leukaemia". Scand J Haematol. 35 (3): 354–7. PMID 4059858.
↑ Sinigaglia R, Gigante C, Bisinella G, Varotto S, Zanesco L, Turra S (2008). "Musculoskeletal manifestations in pediatric acute leukemia". J Pediatr Orthop. 28 (1): 20–8. doi:10.1097/BPO.0b13e31815ff350. PMID 18157042.
↑ Pui CH (January 2009). "Acute lymphoblastic leukemia: introduction". Semin. Hematol. 46 (1): 1–2. doi:10.1053/j.seminhematol.2008.09.011. PMC 2638983. PMID 19100362.
↑ Terwilliger T, Abdul-Hay M (June 2017). "Acute lymphoblastic leukemia: a comprehensive review and 2017 update". Blood Cancer J. 7 (6): e577. doi:10.1038/bcj.2017.53. PMC 5520400. PMID 28665419.
↑ Aboud, H.; Treleaven, J.; Carter, R.; O'Brien, M.; Powels, R. (1991). "An adult with common acute lymphoblastic leukaemia (C-ALL) presenting with skin infiltration". British Journal of Dermatology. 124 (1): 84–85. doi:10.1111/j.1365-2133.1991.tb03287.x. ISSN 0007-0963.
↑ Brix N, Rosthøj S, Herlin T, Hasle H (2015). "Arthritis as presenting manifestation of acute lymphoblastic leukaemia in children". Arch Dis Child. 100 (9): 821–5. doi:10.1136/archdischild-2014-307751. PMID 26216831.

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[pmid27647842-1] Clarke RT, Van den Bruel A, Bankhead C, Mitchell CD, Phillips B, Thompson MJ (October 2016). "Clinical presentation of childhood leukaemia: a systematic review and meta-analysis". Arch. Dis. Child. 101 (10): 894–901. doi:10.1136/archdischild-2016-311251. PMID 27647842.

[pmid4059858-2] Vesterby A, Myhre Jensen O (September 1985). "Aseptic bone/bone marrow necrosis in leukaemia". Scand J Haematol. 35 (3): 354–7. PMID 4059858.

[pmid18157042-3] Sinigaglia R, Gigante C, Bisinella G, Varotto S, Zanesco L, Turra S (2008). "Musculoskeletal manifestations in pediatric acute leukemia". J Pediatr Orthop. 28 (1): 20–8. doi:10.1097/BPO.0b13e31815ff350. PMID 18157042.

[pmid19100362-4] Pui CH (January 2009). "Acute lymphoblastic leukemia: introduction". Semin. Hematol. 46 (1): 1–2. doi:10.1053/j.seminhematol.2008.09.011. PMC 2638983. PMID 19100362.

[pmid28665419-5] Terwilliger T, Abdul-Hay M (June 2017). "Acute lymphoblastic leukemia: a comprehensive review and 2017 update". Blood Cancer J. 7 (6): e577. doi:10.1038/bcj.2017.53. PMC 5520400. PMID 28665419.

[AboudTreleaven1991-6] Aboud, H.; Treleaven, J.; Carter, R.; O'Brien, M.; Powels, R. (1991). "An adult with common acute lymphoblastic leukaemia (C-ALL) presenting with skin infiltration". British Journal of Dermatology. 124 (1): 84–85. doi:10.1111/j.1365-2133.1991.tb03287.x. ISSN 0007-0963.

[pmid26216831-7] Brix N, Rosthøj S, Herlin T, Hasle H (2015). "Arthritis as presenting manifestation of acute lymphoblastic leukaemia in children". Arch Dis Child. 100 (9): 821–5. doi:10.1136/archdischild-2014-307751. PMID 26216831.

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