Mucinous cystadenocarcinoma differential diagnosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

Mucinous cystadenocarcinoma must be differentiated from mucinous cystadenoma, serous cystadenoma, and pseudocyst.

Differentiating Mucinous cystadenocarcinoma from other Diseases

Mucinous cystadenocarcinoma of ovary

Mucinous borderline tumor of the ovary
Metastatic mucinous carcinoma^[1]

Mucinous cystadenocarcinoma of pancreas

Mucinous cystadenoma of pancreas
Pancreatic pseudocyst
Serous cystadenoma of pancreas

Mucinous cystadenocarcinoma of appendix

Appendicitis
Nonmucinous appendiceal tumors
Mesenteric cyst^[2]^[3]

			Lab Findings	Imaging			Histopathology
Mucinous cystadenocarcinoma of ovary	Clinical manifestations		Para-clinical findings					Gold standard
	Sign and symptoms	Physical examination	Para-clinical findings
			Lab Findings	US	CT	MRI	Histopathology
Mucinous borderline tumor of the ovary	Asymptomatic initially Vaginal bleeding Abdominal mass	Increased abdominal girth Abdominal mass	Decreased Hb Raised CEA	Localizes tumor	Demarcates the cancer	To visulaize the extent of the tumor	Large multiloculated cystic masses mucus-containing cysts	Image guided biopsy and histopathological analysis
Metastatic mucinous carcinoma^[4]	Ascities Abdominal mass Abdominal fullness Early satiety Fatigue Bowel obstruction Pleural effusion Pelvic or abdominal pain Venous thromboembolism Bloating Urinary frequency	Increased abdominal girth Abdominal mass Ascities Pallor Lymphadenopathy	Incresed CA-125 Decreased-Hb Raised CEA	For the assessment for ascites and to the extent of cancer	Shows intra-abdominal spread	Shows distant metastasis and extent of the tumor	Mucinous differentiation Tall columnar cells with apical mucin Endocervical or intestinal-like appearance Back-to-back cribriform glands with confluent growth pattern Invasive morphology	Image-guided biopsy of patients with peritoneal metastasis and histopathological analysis

Mucinous cystadenocarcinoma of pancreas	Symptoms	Physical examination	Lab Findings	US	CT	MRI	Histopathology	Gold standard
Mucinous cystadenoma of pancreas^[5]^[6]^[7]	Asymptomatic Epigastric fullness Abdominal mass Nausea and vomiting Back pain						Solitary, multilocular or unilocular cysts with a fibrotic wall and containing mucin. Columnar epithelium lined mucin-producing cysts with different level of dysplasia.
Pancreatic pseudocyst
Serous cystadenoma of pancreas



Mucinous cystadenocarcinoma of appendix	Symptoms	Physical examination	Lab 1	US	CT	MRI	Histopathology	Gold standard
Appendicitis
Nonmucinous appendiceal tumors
Mesenteric cyst^[2]

References

↑ Ovary Epithelial tumors. Atlasgeneticsoncology (2016).http://atlasgeneticsoncology.org/Tumors/OvaryEpithTumID5230.html Accessed on February 29, 2016
↑ ^2.0 ^2.1 Hamilton DL, Stormont JM (1989). "The volcano sign of appendiceal mucocele". Gastrointest. Endosc. 35 (5): 453–6. PMID 2792684.
↑ Raijman I, Leong S, Hassaram S, Marcon NE (March 1994). "Appendiceal mucocele: endoscopic appearance". Endoscopy. 26 (3): 326–8. doi:10.1055/s-2007-1008979. PMID 8076556.
↑ Hewitt MJ, Anderson K, Hall GD, Weston M, Hutson R, Wilkinson N, Perren TJ, Lane G, Spencer JA (January 2007). "Women with peritoneal carcinomatosis of unknown origin: Efficacy of image-guided biopsy to determine site-specific diagnosis". BJOG. 114 (1): 46–50. doi:10.1111/j.1471-0528.2006.01176.x. PMID 17233859.
↑ Campbell F, Azadeh B (April 2008). "Cystic neoplasms of the exocrine pancreas". Histopathology. 52 (5): 539–51. doi:10.1111/j.1365-2559.2007.02856.x. PMID 17903202.
↑ Garcea G, Ong SL, Rajesh A, Neal CP, Pollard CA, Berry DP, Dennison AR (2008). "Cystic lesions of the pancreas. A diagnostic and management dilemma". Pancreatology. 8 (3): 236–51. doi:10.1159/000134279. PMID 18497542.
↑ Sarr MG, Carpenter HA, Prabhakar LP, Orchard TF, Hughes S, van Heerden JA, DiMagno EP (February 2000). "Clinical and pathologic correlation of 84 mucinous cystic neoplasms of the pancreas: can one reliably differentiate benign from malignant (or premalignant) neoplasms?". Ann. Surg. 231 (2): 205–12. PMC 1420988. PMID 10674612.

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[1] Ovary Epithelial tumors. Atlasgeneticsoncology (2016).http://atlasgeneticsoncology.org/Tumors/OvaryEpithTumID5230.html Accessed on February 29, 2016

[pmid2792684-2] 2.0 ^2.1 Hamilton DL, Stormont JM (1989). "The volcano sign of appendiceal mucocele". Gastrointest. Endosc. 35 (5): 453–6. PMID 2792684.

[pmid8076556-3] Raijman I, Leong S, Hassaram S, Marcon NE (March 1994). "Appendiceal mucocele: endoscopic appearance". Endoscopy. 26 (3): 326–8. doi:10.1055/s-2007-1008979. PMID 8076556.

[pmid17233859-4] Hewitt MJ, Anderson K, Hall GD, Weston M, Hutson R, Wilkinson N, Perren TJ, Lane G, Spencer JA (January 2007). "Women with peritoneal carcinomatosis of unknown origin: Efficacy of image-guided biopsy to determine site-specific diagnosis". BJOG. 114 (1): 46–50. doi:10.1111/j.1471-0528.2006.01176.x. PMID 17233859.

[pmid17903202-5] Campbell F, Azadeh B (April 2008). "Cystic neoplasms of the exocrine pancreas". Histopathology. 52 (5): 539–51. doi:10.1111/j.1365-2559.2007.02856.x. PMID 17903202.

[pmid18497542-6] Garcea G, Ong SL, Rajesh A, Neal CP, Pollard CA, Berry DP, Dennison AR (2008). "Cystic lesions of the pancreas. A diagnostic and management dilemma". Pancreatology. 8 (3): 236–51. doi:10.1159/000134279. PMID 18497542.

[pmid10674612-7] Sarr MG, Carpenter HA, Prabhakar LP, Orchard TF, Hughes S, van Heerden JA, DiMagno EP (February 2000). "Clinical and pathologic correlation of 84 mucinous cystic neoplasms of the pancreas: can one reliably differentiate benign from malignant (or premalignant) neoplasms?". Ann. Surg. 231 (2): 205–12. PMC 1420988. PMID 10674612.

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