Neurofibroma laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]
Overview
Immunohistochemistry of neurofibroma shows positivity for S100, CD34, and factor XIIIa and negativity for EMA (except in plexiform neurofibromas).
Laboratory Findings
Immunohistochemistry of neurofibroma is as follows:
- Positive for:
- S100
- Sox10
- CD34 (focal)
- Factor XIIIa (focal)
- Neurofilament (and Bielshowsky)
- GFAP
- Calretinin (focal)
- Negative for:
| Immunohistochemical stain | Neurofibroma | Schwannoma |
|---|---|---|
| S-100 and Sox10 | Moderate positivity | Strong, diffuse positivity |
| CD34 | Moderate | Scattered cells in Antoni B areas |
| Neurofilament (and Bielshowsky) | Stains entrapped axons within lesion | Stains peripherally located axons of parent nerve |
| Factor XIIIa | Moderate | Negative to focal |
| Calretinin | Negative to focal | Moderate |
| GFAP | Variable, weak | Variable, moderate |