Retinoblastoma historical perspective
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
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Overview
Retinoblastoma was first described in 1809 by James Wardrop.
Historical Perspective
- In 1657, Dr. Petrus Pawius, an anatomist from Amsterdam, described a tumor resembling retinoblastoma for the first time.[1]
- In 1767, Dr. Hayes, a surgeon, was first to describe the bilateral form of retinoblastoma.
- In 1809, Dr. James Wardrop, Scottish surgeon, an ophthalmologist, first described the retinoblastoma tumor.
- In 1971, Dr. Knudson proposed the two-hit hypothesis which gives the light to the pathogenesis of the familial and sporadic form of the tumor.[2]
- In 1899, Flexner and Wintersteiner were the first to discover the association between tumor rosettes and photoreceptors of the adult retina.
- In 1920s Verhoeff claimed that the tumor arose from embryonic retinal cells and hence proposed the name "retinoblastoma".
Landmark Events in the Development of Treatment Strategies
- In 1851, Mr. Helmholtz invented ophthalmoscope, with which the study of tumor became more possible.[1]
- Dr. James Wardrop was also the first who proposed the idea that early enucleation of the eye might save the life of the patient.
References
- ↑ 1.0 1.1 Albert, Daniel M. (1987). "Historic Review of Retinoblastoma". Ophthalmology. 94 (6): 654–662. doi:10.1016/S0161-6420(87)33407-4. ISSN 0161-6420.
- ↑ Knudson AG (April 1971). "Mutation and cancer: statistical study of retinoblastoma". Proc. Natl. Acad. Sci. U.S.A. 68 (4): 820–3. PMC 389051. PMID 5279523.