Mucinous cystadenocarcinoma natural history

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Qurrat-ul-ain Abid, M.D.[2], Ammu Susheela, M.D. [3]

Overview

If left untreated, most of the patients with mucinous cystadenocarcinoma may be confined to the organ itself. Common complications of mucinous cystadenocarcinoma include metastasis and inguinal hernia. The presence of metastasis is associated with a particularly poor prognosis among patients with mucinous cystadenocarcinoma.

Natural History

• If left untreated, most of the patients with mucinous cystadenocarcinoma may be confined to the organ itself. Some of them may develop metastasis to the gastrointestinal tract.

Complications

• Common complications are:

• Metastasis
• Inguinal hernia

Prognosis

• Advanced stages of mucinous cystadenocarcinoma have an inferior prognosis.
• Mucinous cystadenocarcinoma has a much more favorable prognosis than most other forms of adenocarcinoma. Cases have been documented of continued growth of these lesions over a period of 10 years without symptoms or metastasis. The overall mortality rate appears to be somewhere in the vicinity of 18% to 27%, depending on the criteria that are used to define this entity.
• 5-year survival has been stated to be approximately 50% when treated with cytoreduction (debulking) surgery to remove all of the tumors in the abdomen which is combined with hyperthermic intraoperative peritoneal chemotherapy (HIPEC).