Neurofibroma laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]

Overview

On Immunohistochemistry, neurofibroma stains positive for S100, SOX10, CD34, factor XIIIa, neurofilament, GFAP and calretinin and negative for EMA, keratin, smooth muscle actin, desmin, calponin, caldesmon and p53.

Laboratory Findings

Immunohistochemistry of neurofibroma is as follows:

Immunohistochemical differences between Neurofibroma and Schwannoma
Immunohistochemical stain Neurofibroma Schwannoma
S-100 and SOX10 Moderate positivity Strong, diffuse positivity
CD34 Moderate Scattered cells in Antoni B areas
Neurofilament (and Bielshowsky) Stains entrapped axons within lesion Stains peripherally located axons of parent nerve
Factor XIIIa Moderate Negative to focal
Calretinin Negative to focal Moderate
GFAP Variable, weak Variable, moderate

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