Familial mediterranean fever natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]

Overview

Common complications of familial Mediterranean fever include amyloidosis and increased risk of vasculitis associated disorder Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.

Natural History, Complications, and Prognosis

Natural History

• The symptoms of familial Mediterranean fever usually develop in the first two decades of life and start with symptoms such as fever and serositis.

Serositis may include, but not limited to:

• If left untreated, [#]% of patients with [disease name] may progress to develop amyloidosis, [manifestation 2], and [manifestation 3].

Complications

AA-amyloidosis with renal failure is a complication and may develop without overt crises. AA (amyloid protein) is produced in very large quantities during attacks and at a low rate between them, and accumulates mainly in the kidney, as well as the heart, spleen, gastrointestinal tract and the thyroid.

There appears to be an increase in the risk for developing particular vasculitis related diseases (e.g. Henoch-Schönlein purpura), spondylarthropathy, prolonged arthritis of certain joints and protracted myalgia.

Prognosis

There is no known cure for familial Mediterranean fever. Most people continue to have attacks, but the number and severity of attacks is different from person to person.

• Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [--]%.
• The presence of amyloidosis is associated with a particularly [good/poor] prognosis among patients with familial Mediterranean fever.