Squamous cell carcinoma of the skin risk factors
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Squamous cell carcinoma of the skin Microchapters |
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Differentiating Squamous cell carcinoma of the skin from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2], Raviteja Guddeti, M.B.B.S. [3]
Overview
The risk factors for the Squamous cell carcinoma (SCC) include prolonged sunlight exposure, UV radiation, smoking, drugs etc.
Risk Factors
Common Risk Factors
Common risk factors for the development of the disease inlcude:
- UV light exposure
- UV light damages DNA, initiating a series of changes can result in malignant transformation
- Having skin that burns easily and does not tan or tans poorly
- Light-colored hair
- Older age
- Smoking
Less Common Risk factors
- Northern European ancestry
- Exposure to PUVA phototherapy
- Immunosuppressive treatment
- Exposure to ionizing radiation and other industrial carcinogens
- Chronic inflammation
- Rare inherited disorders
- Xeroderma pigmentosum
- Epidermolysis bullosa
- Albinism
- Epidermodysplasia verruciformis
- Fanconi's anemia
- Arsenic exposure
- Genetic alterations
- Family history
- Drugs
- BRAF inhibitors
- Voriconazole
- Other photosensitizing drugs like ibuprofen and isotretinoin