Ameloblastoma causes

	Ameloblastoma Microchapters
Home
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Ameloblastoma from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X-Ray
CT
MRI
Echocardiography and Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Ameloblastoma causes On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Ameloblastoma causes All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Ameloblastoma causes
CDC on Ameloblastoma causes
Ameloblastoma causes in the news
Blogs on Ameloblastoma causes
Directions to Hospitals Treating Ameloblastoma
Risk calculators and risk factors for Ameloblastoma causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2], Simrat Sarai, M.D. [3]

Overview

There are no established causes for ameloblastoma. It is thought that ameloblastoma may be the result of either decreased expression of matrix metalloproteinase-2 which helps in inhibition of the local invasiveness of ameloblastoma, or it is may be due to increased expression of α5β1 integrin which participate in the local invasiveness of ameloblastoma.

Causes

Common Causes

Common causes of ameloblastoma may include:

Decreased expression of of matrix metalloproteinase-2^[1]^[2]
Increased expression α5β1 integrin

Less Common Causes

Less common causes of ameloblastoma may include:

Mouth or jaw injury^[2]
Infections
Inflammation
Diet lacks in protein or minerals

Genetic Causes

Ameloblastoma is caused by a mutation in the FGFR2-RAS-BRAF V600E gene.^[3]^[4]

References

↑ Jeddy, Nadeem; Jeeva, Sathiya; Jeyapradha, T; Lakshmipathy, P; Saikrishna, P; Ananthalakshmi, R (2013). "The molecular and genetic aspects in the pathogenesis and treatment of ameloblastoma". Journal of Dr. NTR University of Health Sciences. 2 (3): 157. doi:10.4103/2277-8632.117179. ISSN 2277-8632.
↑ ^2.0 ^2.1 Masthan KM, Anitha N, Krupaa J, Manikkam S (April 2015). "Ameloblastoma". J Pharm Bioallied Sci. 7 (Suppl 1): S167–70. doi:10.4103/0975-7406.155891. PMC 4439660. PMID 26015700.
↑ Brown NA, Rolland D, McHugh JB, Weigelin HC, Zhao L, Lim MS, Elenitoba-Johnson KS, Betz BL (November 2014). "Activating FGFR2-RAS-BRAF mutations in ameloblastoma". Clin. Cancer Res. 20 (21): 5517–26. doi:10.1158/1078-0432.CCR-14-1069. PMID 24993163.
↑ Kurppa KJ, Catón J, Morgan PR, Ristimäki A, Ruhin B, Kellokoski J, Elenius K, Heikinheimo K (April 2014). "High frequency of BRAF V600E mutations in ameloblastoma". J. Pathol. 232 (5): 492–8. doi:10.1002/path.4317. PMC 4255689. PMID 24374844.

Template:WH Template:WS

[JeddyJeeva2013-1] Jeddy, Nadeem; Jeeva, Sathiya; Jeyapradha, T; Lakshmipathy, P; Saikrishna, P; Ananthalakshmi, R (2013). "The molecular and genetic aspects in the pathogenesis and treatment of ameloblastoma". Journal of Dr. NTR University of Health Sciences. 2 (3): 157. doi:10.4103/2277-8632.117179. ISSN 2277-8632.

[pmid26015700-2] 2.0 ^2.1 Masthan KM, Anitha N, Krupaa J, Manikkam S (April 2015). "Ameloblastoma". J Pharm Bioallied Sci. 7 (Suppl 1): S167–70. doi:10.4103/0975-7406.155891. PMC 4439660. PMID 26015700.

[pmid24993163-3] Brown NA, Rolland D, McHugh JB, Weigelin HC, Zhao L, Lim MS, Elenitoba-Johnson KS, Betz BL (November 2014). "Activating FGFR2-RAS-BRAF mutations in ameloblastoma". Clin. Cancer Res. 20 (21): 5517–26. doi:10.1158/1078-0432.CCR-14-1069. PMID 24993163.

[pmid24374844-4] Kurppa KJ, Catón J, Morgan PR, Ristimäki A, Ruhin B, Kellokoski J, Elenius K, Heikinheimo K (April 2014). "High frequency of BRAF V600E mutations in ameloblastoma". J. Pathol. 232 (5): 492–8. doi:10.1002/path.4317. PMC 4255689. PMID 24374844.

[1]

[2]

[3]

[4]