Squamous cell carcinoma of the skin diagnostic study of choice

	Squamous cell carcinoma of the skin Microchapters
Home
Patient Info
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Squamous cell carcinoma of the skin from other Diseases
Epidemiology & Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
Chest X Ray
CT Scan
MRI
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Squamous cell carcinoma of the skin diagnostic study of choice On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Squamous cell carcinoma of the skin diagnostic study of choice All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Squamous cell carcinoma of the skin diagnostic study of choice
CDC on Squamous cell carcinoma of the skin diagnostic study of choice
Squamous cell carcinoma of the skin diagnostic study of choice in the news
Blogs on Squamous cell carcinoma of the skin diagnostic study of choice
Directions to Hospitals Treating Squamous cell carcinoma of the skin
Risk calculators and risk factors for Squamous cell carcinoma of the skin diagnostic study of choice

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Roukoz A. Karam, M.D.[2]

Overview

A biopsy is the gold standard test for the diagnosis of squamous cell carcinoma of the skin.

Diagnostic Study of Choice

Study of choice

A biopsy is the gold standard test for the diagnosis of squamous cell carcinoma of the skin.^[1]

Although clinical findings may strongly suggest a diagnosis of cutaneous squamous cell carcinoma, histopathologic examination is necessary to confirm the diagnosis.

Histopathologic examination is also useful for assessment for perineural invasion, tumor differentiation, and tumor depth, factors that are important for tumor staging and prognosis.^[1]

Shave, punch, or excisional biopsies may be used for diagnosis.

Staging

Staging of squamous cell carcinoma of the skin based on the AJCC recommendations:^[2]

**Cutaneous Squamous cell carcinoma**
Grouping	TNM staging
Stage 0	Tis N0 M0
Stage I	T1 N0 M0
Stage II	T2 N0 M0
Stage III	T3 N0 M0
	T1 N1 M0
	T2 N1 M0
	T3 N1 M0
Stage IV	T1 N2 M0
	T2 N2 M0
	T3 N2 M0
	Any T N3 M0
	T4 Any N M0
	Any T Any N M1

For information on the TNM classification of squamous cell carcinoma of the skin, click here.

References

↑ ^1.0 ^1.1 Prieto-Granada C, Rodriguez-Waitkus P (2015). "Cutaneous squamous cell carcinoma and related entities: Epidemiology, clinical and histological features, and basic science overview". Curr Probl Cancer. 39 (4): 206–15. doi:10.1016/j.currproblcancer.2015.07.005. PMID 26239204.
↑ Jambusaria-Pahlajani A, Kanetsky PA, Karia PS, Hwang WT, Gelfand JM, Whalen FM; et al. (2013). "Evaluation of AJCC tumor staging for cutaneous squamous cell carcinoma and a proposed alternative tumor staging system". JAMA Dermatol. 149 (4): 402–10. doi:10.1001/jamadermatol.2013.2456. PMID 23325457.

Template:WH Template:WS

[pmid26239204-1] 1.0 ^1.1 Prieto-Granada C, Rodriguez-Waitkus P (2015). "Cutaneous squamous cell carcinoma and related entities: Epidemiology, clinical and histological features, and basic science overview". Curr Probl Cancer. 39 (4): 206–15. doi:10.1016/j.currproblcancer.2015.07.005. PMID 26239204.

[pmid23325457-2] Jambusaria-Pahlajani A, Kanetsky PA, Karia PS, Hwang WT, Gelfand JM, Whalen FM; et al. (2013). "Evaluation of AJCC tumor staging for cutaneous squamous cell carcinoma and a proposed alternative tumor staging system". JAMA Dermatol. 149 (4): 402–10. doi:10.1001/jamadermatol.2013.2456. PMID 23325457.

[1]

[2]