Cryopyrin-associated periodic syndrome (CAPS)

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]

Synonyms and keywords:

Overview

Cryopyrin-associated periodic syndrome (CAPS) is a rare disease entity encompassing three different clinical phenotypes including Muckle-Wells syndrome (MWS), neonatal-onset multisystem inflammatory disorder (NOMID), and familial cold autoinflammatory syndrome (FCAS). The three aforementioned phenotypes occur due to a common gene mutation.

Diagnosis

Electrocardiogram

There are no ECG findings associated with cryopyrin-associated periodic syndrome.

X-ray

• There are no x-ray findings associated with cryopyrin-associated periodic syndrome.

Echocardiography or Ultrasound

• There are no echocardiography/ultrasound findings associated with cryopyrin-associated periodic syndrome.

CT scan

• There are no CT scan findings associated with cryopyrin-associated periodic syndrome.

MRI

• There are no MRI findings associated with cryopyrin-associated periodic syndrome.

Other Imaging Findings

• There are no other imaging findings associated with cryopyrin-associated periodic syndrome.

Other Diagnostic Studies

• There are no other diagnostic studies associated with cryopyrin-associated periodic syndrome.

Treatment

Medical Therapy

• There is no treatment for cryopyrin-associated periodic syndrome; the mainstay of therapy is supportive care.

Surgery

• Surgical intervention is not recommended for the management of cryopyrin-associated periodic syndrome.

Primary Prevention

• There are no established measures for the primary prevention of cryopyrin-associated periodic syndrome.

Secondary Prevention

• There are no established measures for the secondary prevention of cryopyrin-associated periodic syndrome.

References

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