Teratoma historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Template:MBT
Overview
Historical Perspective
The recognition of teratomas stretches in time from fragmentary descriptions in ancient times to increasingly frequent gross anatomical observations in the 17th, 18th, and 19th centuries. Clinical observations of the biologic behavior of teratomas likewise expanded from isolated descriptions of patients with tumors in various locations to reports of series of cases with increasing knowledge of clinical signs and symptoms. The understanding of the genesis of these tumors, initially attributed to demons and various forms of sexual misbehavior, languished half-buried under the weight of 19th century speculations (Pauly, 1875) until experimental biologists working in the past 15-20 yr began to unravel some of the mysteries of germ cell development and cellular differentiation.
Prior to the opening of bodies in Renaissance Europe, the teratoma most readily observed would have been that originating in the sacrococcygeal area and presenting at birth as a grotesque protrusion.
Discovery
- There is limited information about the historical perspective of [disease name].
OR
- Teratoma was first discovered during 17th century by frequent observations of anatomical distortions of body. [1]
- The association between [important risk factor/cause] and [disease name] was made in/during [year/event].
- In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].
- In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].
Landmark Events in the Development of Treatment Strategies
Impact on Cultural History
Famous Cases
The following are a few famous cases of [disease name]: