Paraneoplastic syndrome (patient information)
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Paraneoplastic syndrome |
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Paraneoplastic syndrome On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Gertrude Djouka, M.D.[2]
What is a paraneoplastic syndrome?
A neoplasm is an abnormal growth in your body that may be cancerous. If something is “neoplastic,” it has to do with the neoplasm. A paraneoplastic syndrome is a set of symptoms that are caused by a cancer. The symptoms happen in a different area of your body from your cancer.
Most people with cancer don’t get a paraneoplastic syndrome.
Causes
Paraneoplastic syndromes are caused by your cancer making hormones or your immune system making antibodies (substances that protect your body against certain infection) that flow through your blood
Paraneoplastic syndromes cause different symptoms depending on the tissues and organs they occur in
About 1 out of 5 people with cancer get a paraneoplastic syndrome—it's most common with lung cancer
What are the symptoms of paraneoplastic syndromes?
General symptoms
Fever
Night sweats
Loss of appetite
Weight loss
Skin symptoms
Itching
Skin flushing or blushing, causing your face, neck, or upper chest to become warm and red
You may get noncancerous skin bumps or shingles (a painful rash of fluid-filled blisters caused by the same virus that causes chickenpox)
Neurologic (brain, spinal cord, and nerve) symptoms
Weakness or loss of strength
Loss of feeling Slower reflexes
Trouble using different parts of your body the way you want, such as your arms or legs
Trouble speaking
Dizziness
Double vision (when you see 2 of the same object) or being unable to control your eye movements
The cancer can cause these symptoms without pushing on your nerves or spinal cord
Endocrine (hormone system) symptoms
Weakness
Weight gain
High blood pressure or heart valve problems
Confusion
Kidney problems
Red, warm skin
Wheezing
Diarrhea
Other symptoms
Muscle swelling that causes weakness and soreness Painful swelling of your joints that may change the shape of your fingers and toes Changes to your blood cells (red blood cells, white blood cells, and platelets)