Extranodal NK-T-cell lymphoma epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2] Sowminya Arikapudi, M.B,B.S. [3]
Overview
Epidemiology and Demographics
Mortality rate
- NK cell lymphoma shows a poor prognosis because of rapid local progression and distant metastasis.
Race
- Natural Killer (NK) cell lymphoma is a rare disease. NK/T cell lymphoma, nasal type (NKTCL) and aggressive NK-cell leukemia (ANKCL) have a higher incidence in Asia, Central, and South America.[1]
- Nk cell lymphoma is usually associated with Epstein-Barr virus infection.[2]
Gender
- Extranodal NK/T-cell lymphoma shows male preponderance.[3]
Region
- NK T cell lymphoma, nasal type (NNKTL) consist 3000-10000 out of 100000 cases of non-Hodgkin lymphoma in Asia and South America and less than 1% in Western countries.
- It is estimated the incidence of NNKTL is higher in Asia by 10-folds.
Age
- The median age of onset is approximately 50 years and it is common in elderly.[4]
- Extranodal NK/T-cell lymphoma is a rare disease in children and often it is associated with mosquito-bite hypersensetivity or other EBV-associated disease.
References
- ↑ Aozasa, Katsuyuki; Takakuwa, Tetsuya; Hongyo, Tadashi; Yang, Woo-Ick (2008). "Nasal NK/T-cell lymphoma: epidemiology and pathogenesis". International Journal of Hematology. 87 (2): 110–117. doi:10.1007/s12185-008-0021-7. ISSN 0925-5710.
- ↑ Hoshida Y, Hongyo T, Jia X, He Y, Hasui K, Dong Z; et al. (2003). "Analysis of p53, K-ras, c-kit, and beta-catenin gene mutations in sinonasal NK/T cell lymphoma in northeast district of China". Cancer Sci. 94 (3): 297–301. doi:10.1111/j.1349-7006.2003.tb01436.x. PMID 12824925.
- ↑ Quintanilla-Martinez, Leticia; Franklin, Janet L; Guerrero, Ivonne; Krenacs, Laszlo; Naresh, K.N; Rama-Rao, Clementina; Bhatia, Kishor; Raffeld, Mark; Magrath, Ian T (1999). "Histological and immunophenotypic profile of nasal NK/T cell lymphomas from Peru: High prevalence of p53 overexpression". Human Pathology. 30 (7): 849–855. doi:10.1016/S0046-8177(99)90147-8. ISSN 0046-8177.
- ↑ Ko, Y H; Cho, E-Y; Kim, J-E; Lee, S-S; Huh, J-R; Chang, H-K; Yang, W-I; Kim, C-W; Kim, S-W; Ree, H J (2004). "NK and NK-like T-cell lymphoma in extranasal sites: a comparative clinicopathological study according to site and EBV status". Histopathology. 44 (5): 480–489. doi:10.1111/j.1365-2559.2004.01867.x. ISSN 0309-0167.