Extranodal NK-T-cell lymphoma epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2] Sowminya Arikapudi, M.B,B.S. [3]
Overview
Epidemiology and Demographics
Mortality rate
- NK cell lymphoma shows a poor prognosis because of rapid local progression and distant metastasis.
Age
- The median age of onset is approximately 50 years and it is common in elderly.[1]
- Extranodal NK/T-cell lymphoma is a rare disease in children and often it is associated with mosquito-bite hypersensetivity or other EBV-associated disease.[2]
Race
- Natural Killer (NK) cell lymphoma is a rare disease. NK/T cell lymphoma, nasal type (NKTCL) and aggressive NK-cell leukemia (ANKCL) have a higher incidence in Asia, Central, and South America.
- Nk cell lymphoma is usually associated with Epstein-Barr virus infection.
Gender
- Extranodal NK/T-cell lymphoma shows male preponderance.
Region
- NK T cell lymphoma, nasal type (NNKTL) consist 3000-10000 out of 100000 cases of non-Hodgkin lymphoma in Asia and South America and less than 1000 in 10000 patient in western countries.[3]
- It is estimated the incidence of NNKTL is higher in Asia by 10-folds.
References
- ↑ Ko, Y H; Cho, E-Y; Kim, J-E; Lee, S-S; Huh, J-R; Chang, H-K; Yang, W-I; Kim, C-W; Kim, S-W; Ree, H J (2004). "NK and NK-like T-cell lymphoma in extranasal sites: a comparative clinicopathological study according to site and EBV status". Histopathology. 44 (5): 480–489. doi:10.1111/j.1365-2559.2004.01867.x. ISSN 0309-0167.
- ↑ Ng, Siok-Bian; Khoury, Joseph D. (2009). "Epstein-Barr Virus in Lymphoproliferative Processes". Advances in Anatomic Pathology. 16 (1): 40–55. doi:10.1097/PAP.0b013e3181916029. ISSN 1072-4109.
- ↑ Aozasa, Katsuyuki; Ohsawa, Masahiko; Tajima, Kazuo; Sasaki, Ryoji; Maeda, Hajime; Matsunaga, Torn; Friedmann, I. (1989). "Nation-wide study of lethal mid-line granuloma in Japan: Frequencies of Wegener's granulomatosis, polymorphic reticulosis, malignant lymphoma and other related conditions". International Journal of Cancer. 44 (1): 63–66. doi:10.1002/ijc.2910440112. ISSN 0020-7136.