Extranodal NK-T-cell lymphoma causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD [2]

Overview

Extranodal NK/T-cell lymphoma is caused by transition mutation of p53.P53 overexpresion has assosiation with poor prognosis.

Extranodal NK/T-cell lymphoma is caused by transition mutation of p53.^[1]
Genetic instability of micro satellites was not found in cases with the disease.^[2]
P53 overexpresion has assosiation with poor prognosis.

↑ Aozasa, Katsuyuki; Takakuwa, Tetsuya; Hongyo, Tadashi; Yang, Woo-Ick (2008). "Nasal NK/T-cell lymphoma: epidemiology and pathogenesis". International Journal of Hematology. 87 (2): 110–117. doi:10.1007/s12185-008-0021-7. ISSN 0925-5710.
↑ Greenblatt MS, Bennett WP, Hollstein M, Harris CC (1994). "Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis". Cancer Res. 54 (18): 4855–78. PMID 8069852.