Extranodal NK-T-cell lymphoma medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
The predominant therapy for extranodal NK-T-cell lymphoma is radiation therapy. Adjunctive chemotherapy and stem cell transplant may be required.
Medical Therapy
- The predominant therapy for extranodal NK-T-cell lymphoma is radiation therapy. Adjunctive chemotherapy and stem cell transplant may be required.[1]
- Therapy of extranodal NK/T cell lymphoma depends on staging of the tumor:[2][3][4]
| Stage | Involvment | Common involvement place | Preferred therapy method | Radiation dosage | Chemotherapy regimen | Alternative |
|---|---|---|---|---|---|---|
| I(E) | Single extranodal involvement | upper aerodigestive tract | Combined modality therapy‡ | 50 Gy RT | DeVIC∞ | |
| II(E) | Stage I(E) +One or more of † involvments | upper aerodigestive tract | ||||
| III(E)• | Stage I (E) + Cervical lymph node involvment + infradiaphragmatic lymph node / Involvment of spleen | Systemic | ||||
| IV | Stage I(E) +isolated distant involvment | Systemic |
†: Cervical lymph node involvement / Involvment of other superdiaphragmatic lymph node regions / Isolated involvment of additional sites in the head and neck
•: Rare
‡: Combined modality therapy is radiation therapy with concurrent chemotherapy
∞:Dexamethasone, Etoposide, Ifosfamide, Carboplatin.
| Therapy | Description |
|---|---|
| Radiation therapy |
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| Chemotherapy |
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| Stem cell transplant |
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References
- ↑ 1.0 1.1 Extranodal NK/T-cell lymphoma, nasal type. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/extranodal-nk-t-cell-lymphoma-nasal-type/?region=on. Accessed on February 02, 2016
- ↑ Dreyling, M.; Thieblemont, C.; Gallamini, A.; Arcaini, L.; Campo, E.; Hermine, O.; Kluin-Nelemans, J. C.; Ladetto, M.; Le Gouill, S.; Iannitto, E.; Pileri, S.; Rodriguez, J.; Schmitz, N.; Wotherspoon, A.; Zinzani, P.; Zucca, E. (2013). "ESMO Consensus conferences: guidelines on malignant lymphoma. part 2: marginal zone lymphoma, mantle cell lymphoma, peripheral T-cell lymphoma". Annals of Oncology. 24 (4): 857–877. doi:10.1093/annonc/mds643. ISSN 1569-8041.
- ↑ Isobe, Koichi; Uno, Takashi; Tamaru, Jun-ichi; Kawakami, Hiroyuki; Ueno, Naoyuki; Wakita, Hisashi; Okada, Jun-ichi; Itami, Jun; Ito, Hisao (2006). "Extranodal natural killer/T-cell lymphoma, nasal type". Cancer. 106 (3): 609–615. doi:10.1002/cncr.21656. ISSN 0008-543X.
- ↑ Li, Ye-Xiong; Yao, Bo; Jin, Jing; Wang, Wei-Hu; Liu, Yue-Ping; Song, Yong-Wen; Wang, Shu-Lian; Liu, Xin-Fan; Zhou, Li-Qiang; He, Xiao-Hui; Lu, Ning; Yu, Zi-Hao (2006). "Radiotherapy As Primary Treatment for Stage IE and IIE Nasal Natural Killer/T-Cell Lymphoma". Journal of Clinical Oncology. 24 (1): 181–189. doi:10.1200/JCO.2005.03.2573. ISSN 0732-183X.