Germ cell tumor causes

• The cause of germ cell tumor is not understood fully but there are many risk factors that believed to play a role in the development of germ cell tumors.

The etiology of yolk sac tumors (YSTs) is essentially unknown. It is speculated that hypermethylation of the RUNX3 gene promoter and overexpression of GATA-4, a transcription factor that regulates differentiation and function of yolk sac endoderm, may play important roles in the pathogenesis of yolk sac tumors (YSTs)

Germ cell tumor	causes
General Causes
Dysgerminoma
Seminoma	Common causes Cryptorchidism Undescended testis Abdominal testis Trauma Mumps Maternal estrogen exposure Genetic Causes Seminoma is caused by a mutation in the KIT gene. 12p11.2-p12.1 chromosomal amplifications and deletions observed in majority of cases.
Embryonal cell carcinoma
Choriocarcinoma	Abnormal trophoblastic population undergoing hyperplasia and anaplasia can give rise to choriocarcinoma. Gestational type arises following a hydatidiform mole, normal pregnancy, or most commonly, abortion. Non-gestational type arises from pluripotent germ cells.
Yolk sac tumor