Zollinger-Ellison syndrome other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]

Overview

Other diagnostic studies for Zollinger-Ellison syndrome include upper endoscopy, which demonstrates erosive esophagitis, thickened gastric folds, and antral erosions.

Other Diagnostic Studies

Upper Endoscopy

Upper endoscopy may be helpful in the diagnosis of Zollinger-Ellison syndrome. Findings may include:^[1]

Esophageal erosions
Thickened gastric folds
Antral erosions
Bulbar erosions and ulcerations
Post-bulbar erosions and ulcerations

Immunostaining

Immunostaining for chromogranin A and synaptophysin is an important feature for the diagnosis of neuroendocrine tumors^[2]
In order to differentiate from other neuroendocrine tumors gastrin immunostaining may be helpful in differentiation.^[2]
Diagnostic accuracy of imaging for localization of gastrinoma: ^[3] ^[4]

References

↑ Lee, Wan-Sik; Koh, Yang-Seok; Kim, Jung-Chul; Park, Chang-Hwan; Joo, Young-Eun; Kim, Hyun-Soo; Cho, Chol-Kyoon; Choi, Sung-Kyu; Rew, Jong-Sun; Kim, Sei-Jong (2005). "Abdominal gastrinoma". BMC Cancer. 5 (1): 85. doi:10.1186/1471-2407-5-85. ISSN 1471-2407.
↑ ^2.0 ^2.1 Cingam S, Karanchi H. PMID 28722872. Missing or empty |title= (help)
↑ Epelboym I, Mazeh H (2014). "Zollinger-Ellison syndrome: classical considerations and current controversies". Oncologist. 19 (1): 44–50. doi:10.1634/theoncologist.2013-0369. PMC 3903066. PMID 24319020.
↑ Hung PD, Schubert ML, Mihas AA (2003). "Zollinger-Ellison Syndrome". Curr Treat Options Gastroenterol. 6 (2): 163–170. PMID 12628075.

[LeeKoh2005-1] Lee, Wan-Sik; Koh, Yang-Seok; Kim, Jung-Chul; Park, Chang-Hwan; Joo, Young-Eun; Kim, Hyun-Soo; Cho, Chol-Kyoon; Choi, Sung-Kyu; Rew, Jong-Sun; Kim, Sei-Jong (2005). "Abdominal gastrinoma". BMC Cancer. 5 (1): 85. doi:10.1186/1471-2407-5-85. ISSN 1471-2407.

[pmid28722872-2] 2.0 ^2.1 Cingam S, Karanchi H. PMID 28722872. Missing or empty |title= (help)

[pmid24319020-3] Epelboym I, Mazeh H (2014). "Zollinger-Ellison syndrome: classical considerations and current controversies". Oncologist. 19 (1): 44–50. doi:10.1634/theoncologist.2013-0369. PMC 3903066. PMID 24319020.

[pmid12628075-4] Hung PD, Schubert ML, Mihas AA (2003). "Zollinger-Ellison Syndrome". Curr Treat Options Gastroenterol. 6 (2): 163–170. PMID 12628075.

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