Extranodal NK-T-cell lymphoma classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2] Sowminya Arikapudi, M.B,B.S. [3]
Overview
In contrast with B-cell lymphoma, classification of such a rare neoplasm has been controversial. Extranodal NK-T-cell lymphoma may be classified according to WHO into 2 subtypes: NK cell-derived neoplasms, namely, aggressive NK cell leukemia and extranodal NK-T-cell lymphoma, nasal type. Based on the organ involvement, extranodal NK-T-cell lymphoma may be classified into extranodal NK-T-cell lymphoma, nasal type, and extranodal NK-T-cell lymphoma, extra nasal type which contains two major subclass: Enteropathy type and subcutaneous panniculitis-like.
Classification
- In contrast with B-cell lymphoma, classification of such a rare neoplasm has been controversial, since the cytologic features have not been very useful. Further, by many entities, T-cell and natural killer cell (NK) neoplasms do not share any similar immuno-phenotype. Because of such matter, clinical features became handier for classification and somehow even more important than the precise cell of origin.[1][2]
- Since the majority of cytotoxic T-cell and NK cell lymphomas are located out of lymph nodes, the gene expressing cytotoxic molecules may predispose to apoptosis by tumor cells and by standard cells.
- Three major categories of extranodal T/NK cell tumors include:[3]
- Extranodal NK/T-cell lymphoma, nasal type lymphoma
- Extranodal NK/T-cell lymphoma, enteropathy type lymphoma
- Extranodal NK/T-cell lymphoma, subcutaneous panniculitis-like
Extranodal NK-T-cell lymphoma may be classified according to WHO into 2 subtypes:
- NK cell-derived neoplasms, namely, aggressive NK cell leukemia
- Extranodal NK/T-cell lymphoma, nasal type
Based on the organ involvement, extranodal NK-T-cell lymphoma may be classified into:[4][1]
- Extranodal NK-T-cell lymphoma, nasal type
- Extranodal NK-T-cell lymphoma, extra nasal type
| Name | Description |
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| Extranodal NK-T-cell lymphoma, nasal type |
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| Extranodal NK-T-cell lymphoma, extra nasal type |
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Natural Killer cell neoplasms are classified by the world health organization (WHO) into:
- NK/T-cell lymphoma, nasal type (NKTCL) [5]
- Aggressive NK-cell leukemia (ANKCL)
- Chronic lymphoproliferative disorders of NK-cell
References
- ↑ 1.0 1.1 Extranodal natural killer/T-cell lymphoma. BioMedCentral. http://jhoonline.biomedcentral.com/articles/10.1186/1756-8722-6-86. Accessed on February 19, 2016
- ↑ Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type. Hindawi Publishing Corporation. http://www.hindawi.com/journals/ah/2010/627401/. Accessed on February 18, 2016,
- ↑ Jaffe ES, Krenacs L, Raffeld M (2003). "Classification of cytotoxic T-cell and natural killer cell lymphomas". Semin Hematol. 40 (3): 175–84. PMID 12876666.
- ↑ Extranodal NK/T-cell lymphoma, nasal type. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/extranodal-nk-t-cell-lymphoma-nasal-type/?region=on. Accessed on February 18, 2016
- ↑ Lima M (2013). "Aggressive mature natural killer cell neoplasms: from epidemiology to diagnosis". Orphanet J Rare Dis. 8: 95. doi:10.1186/1750-1172-8-95. PMC 3770456. PMID 23816348.