Extranodal NK-T-cell lymphoma epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD [2] Sowminya Arikapudi, M.B,B.S. [3]

Overview

NK cell lymphoma shows a poor prognosis because of rapid local progression and distant metastasis.The median age of onset is approximately 50 years and it is common in elderly.Extranodal NK/T-cell lymphoma is a rare disease in children and often it is associated with mosquito-bite hypersensetivity or other EBV-associated disease.Natural Killer (NK) cell lymphoma is a rare disease. NK/T cell lymphoma, nasal type (NKTCL) and aggressive NK-cell leukemia (ANKCL) have a higher incidence in Asia, Central, and South America.NK T cell lymphoma, nasal type (NNKTL) consist 3000-10000 out of 100000 cases of non-Hodgkin lymphoma in Asia and South America and less than 1000 in 10000 patient in western countries

Epidemiology and Demographics

Mortality rate

NK cell lymphoma shows a poor prognosis because of rapid local progression and distant metastasis^[1].

Age

The median age of onset is approximately 50 years and it is common in elderly^[2].
Extranodal NK/T-cell lymphoma is a rare disease in children and often it is associated with mosquito-bite hypersensitivity or other EBV-associated disease.

Race

Natural Killer (NK) cell lymphoma is a rare disease. NK/T cell lymphoma, nasal type (NKTCL) and aggressive NK-cell leukemia (ANKCL) have a higher incidence in Asia, Central, and South America^[3].
Nk cell lymphoma is usually associated with Epstein-Barr virus infection.

Gender

Extranodal NK/T-cell lymphoma shows male preponderance^[4].

Region

Extranodal NK T cell lymphoma, nasal type (NNKTL) consist 3000-10000 out of 100000 cases of non-Hodgkin lymphoma in Asia and South America and less than 1000 in 10000 patient in western countries.
It is estimated the incidence of NNKTL is higher in Asia by 10-folds.

References

↑ Ko, Y H; Cho, E-Y; Kim, J-E; Lee, S-S; Huh, J-R; Chang, H-K; Yang, W-I; Kim, C-W; Kim, S-W; Ree, H J (2004). "NK and NK-like T-cell lymphoma in extranasal sites: a comparative clinicopathological study according to site and EBV status". Histopathology. 44 (5): 480–489. doi:10.1111/j.1365-2559.2004.01867.x. ISSN 0309-0167.
↑ Takahashi, E; Asano, N; Li, C; Tanaka, T; Shimada, K; Shimada, S; Yoshino, T; Kojima, M; Hara, K; Eimoto, T; Nakamura, S (2008). "Nodal T/NK-cell lymphoma of nasal type: a clinicopathological study of six cases". Histopathology. 52 (5): 585–596. doi:10.1111/j.1365-2559.2008.02997.x. ISSN 0309-0167.
↑ Ko, Y H; Cho, E-Y; Kim, J-E; Lee, S-S; Huh, J-R; Chang, H-K; Yang, W-I; Kim, C-W; Kim, S-W; Ree, H J (2004). "NK and NK-like T-cell lymphoma in extranasal sites: a comparative clinicopathological study according to site and EBV status". Histopathology. 44 (5): 480–489. doi:10.1111/j.1365-2559.2004.01867.x. ISSN 0309-0167.
↑ Ko, Y H; Cho, E-Y; Kim, J-E; Lee, S-S; Huh, J-R; Chang, H-K; Yang, W-I; Kim, C-W; Kim, S-W; Ree, H J (2004). "NK and NK-like T-cell lymphoma in extranasal sites: a comparative clinicopathological study according to site and EBV status". Histopathology. 44 (5): 480–489. doi:10.1111/j.1365-2559.2004.01867.x. ISSN 0309-0167.

[KoCho2004-1] Ko, Y H; Cho, E-Y; Kim, J-E; Lee, S-S; Huh, J-R; Chang, H-K; Yang, W-I; Kim, C-W; Kim, S-W; Ree, H J (2004). "NK and NK-like T-cell lymphoma in extranasal sites: a comparative clinicopathological study according to site and EBV status". Histopathology. 44 (5): 480–489. doi:10.1111/j.1365-2559.2004.01867.x. ISSN 0309-0167.

[TakahashiAsano2008-2] Takahashi, E; Asano, N; Li, C; Tanaka, T; Shimada, K; Shimada, S; Yoshino, T; Kojima, M; Hara, K; Eimoto, T; Nakamura, S (2008). "Nodal T/NK-cell lymphoma of nasal type: a clinicopathological study of six cases". Histopathology. 52 (5): 585–596. doi:10.1111/j.1365-2559.2008.02997.x. ISSN 0309-0167.

[KoCho20042-3] Ko, Y H; Cho, E-Y; Kim, J-E; Lee, S-S; Huh, J-R; Chang, H-K; Yang, W-I; Kim, C-W; Kim, S-W; Ree, H J (2004). "NK and NK-like T-cell lymphoma in extranasal sites: a comparative clinicopathological study according to site and EBV status". Histopathology. 44 (5): 480–489. doi:10.1111/j.1365-2559.2004.01867.x. ISSN 0309-0167.

[KoCho20043-4] Ko, Y H; Cho, E-Y; Kim, J-E; Lee, S-S; Huh, J-R; Chang, H-K; Yang, W-I; Kim, C-W; Kim, S-W; Ree, H J (2004). "NK and NK-like T-cell lymphoma in extranasal sites: a comparative clinicopathological study according to site and EBV status". Histopathology. 44 (5): 480–489. doi:10.1111/j.1365-2559.2004.01867.x. ISSN 0309-0167.

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