Paraneoplastic syndrome (patient information)
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Paraneoplastic syndrome |
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Paraneoplastic syndrome On the Web |
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Risk calculators and risk factors for Paraneoplastic syndrome |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Gertrude Djouka, M.D.[2]
Overview
A paraneoplastic syndrome is a disease or symptom that is the consequence of the presence of cancer in the body, but is not due to the local presence of cancer cells. These phenomena are mediated by humoral factors (by hormones or cytokines) excreted by tumor cells or by an immune response against the tumor. Sometimes the symptoms of paraneoplastic syndromes show even before the diagnosis of a malignancy. A paraneoplastic syndrome is a set of symptoms that are caused by a cancer. The symptoms happen in a different area of your body from your cancer.
What are the Symptoms of Paraneoplastic syndrome?
- Paraneoplastic syndromes cause different symptoms depending on the tissues and organs they are involved
- About 20% of people with cancer get a paraneoplastic syndrome and the most common cancers are lung, hepatocellular, ovarian, breast, gastric , pancreatic and other cancers.
General symptoms
- General symptoms of paraneoplastic syndrome include:
Skin symptoms
Neurologic (brain, spinal cord, and nerve) symptoms
- Weakness or loss of strength
- Loss of feeling
- Slower reflexes
- Trouble using different parts of your body the way you want, such as your arms or legs
- Trouble speaking
- Dizziness
- Double vision (when you see two of the same object) or being unable to control your eye movements
- The cancer can cause these symptoms without pushing on your nerves or spinal cord.
Endocrine (hormone system) symptoms
Other symptoms
- Muscle swelling that causes weakness and soreness
- Painful swelling of the joints that may change the shape of the fingers and toes
- Changes to the blood cells (red blood cells, white blood cells, and platelets)
What Causes Paraneoplastic syndrome?
- Paraneoplastic syndromes may be caused by two different mechanisms:
Who is at Highest Risk?
Diagnosis
When to Seek Urgent Medical Care?
Treatment Options
- The tumor and/or cancer are treated first, followed by efforts to decrease the autoimmune response, either through steroids or high-dose intravenous immunoglobulin, or irradiation.
- Plasmapheresis, a process that exchanges antibodies of the blood, may ease symptoms in people with paraneoplastic disorders that affected the peripheral nervous system.
- Speech and physical therapy may help individuals regain some functions.
Where to find Medical Care for Paraneoplastic syndrome?
Prevention
What to Expect (Outlook/Prognosis)?
- There are no cures for paraneoplastic syndromes.
- The type and stage of the original cancer determines the prognosis.