Cardiac amyloidosis future or investigational therapies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]; Aarti Narayan, M.B.B.S [3]
Overview
New therapies targeting the serum amyloid protein (SAP), which is an excellent immunogen and a universal component of all amyloid deposits, using monoclonal antibodies are currently being investigated.
Future or Investigational Therapies
Possible future treatment options which are currently being investigated include:
- Anti-SAP antibody[1]
- CPHPC:[2] CPHPC, also called R-1-[6-[R-2-carboxy-pyrrolidin-1-yl]-6-oxo-hexanoyl]pyrrolidine-2-carboxylic acid, is a competitive inhibitor of SAP binding to amyloid fibrils. CPHPC is a proline-derived small palindromic molecule able to strip amyloid P (AP) from deposits by reducing levels of circulating serum amyloid protein (SAP). It also cross-links and dimerizes SAP, which is cleared rapidly by the liver. The SAP-amyloid association has also been identified as a possible drug target for anti-amyloid therapy, with the recent development and first stage clinical trials of CPHPC for amyloidosis.
- Diflunisal[3]
- Eprodisate[4]
- Pomalidomide (analogue of thalidomide)[5][6]
References
- ↑ Bodin K, Ellmerich S, Kahan MC; et al. (2010). "Antibodies to human serum amyloid P component eliminate visceral amyloid deposits". Nature. 468 (7320): 93–7. doi:10.1038/nature09494. PMC 2975378. PMID 20962779. Unknown parameter
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ignored (help) - ↑ Pepys MB, Herbert J, Hutchinson WL, Tennent GA, Lachmann HJ, Gallimore JR, Lovat LB, Bartfai T, Alanine A, Hertel C, Hoffmann T, Jakob-Roetne R, Norcross RD, Kemp JA, Yamamura K, Suzuki M, Taylor GW, Murray S, Thompson D, Purvis A, Kolstoe S, Wood SP, Hawkins PN (2002). "Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis". Nature. 417 (6886): 254–9. doi:10.1038/417254a. PMID 12015594.
- ↑ Sekijima Y, Dendle MA, Kelly JW (2006). "Orally administered diflunisal stabilizes transthyretin against dissociation required for amyloidogenesis". Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 13 (4): 236–49. doi:10.1080/13506120600960882. PMID 17107884. Unknown parameter
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ignored (help) - ↑ Dember LM, Hawkins PN, Hazenberg BP; et al. (2007). "Eprodisate for the treatment of renal disease in AA amyloidosis". The New England Journal of Medicine. 356 (23): 2349–60. doi:10.1056/NEJMoa065644. PMID 17554116. Unknown parameter
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ignored (help) - ↑ Dispenzieri A, Buadi F, Laumann K; et al. (2012). "Activity of pomalidomide in patients with immunoglobulin light-chain amyloidosis". Blood. 119 (23): 5397–404. doi:10.1182/blood-2012-02-413161. PMID 22493299. Unknown parameter
|month=
ignored (help) - ↑ Elkinson S, McCormack PL (2013). "Pomalidomide: first global approval". Drugs. 73 (6): 595–604. doi:10.1007/s40265-013-0047-x. PMID 23572409. Unknown parameter
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ignored (help)