Amyloidosis physical examination

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Jesus Rosario Hernandez, M.D. [2]

Overview

Common findings in amyloidosis include petechiae, ecchymosis, parotid gland enlargement, increased intraocular pressure, enlarged tongue, hepatomegaly, carpal tunnel syndrome, and Raynaud's phenomenon.

Physical Examination

Physical examination of patients withamyloidosis is usually remarkable for waxy thickening, easy bruising, purpura, macroglossia, parotid gland and submandibular gland enlargement, edema, numbness and paresthesia.^[1]^[2]

Appearance of the Patient

Patients with amyloidosis usually appear normal.

Vital signs

Skin

Waxy thickening
Easy bruising (ecchymoses)
Subcutaneous nodules or plaques
Purpura
Petechiae
Brittle nails
Edema
Diffuse or patchy alopecia
Nail dystrophy
Brittle nails
Plaques may be seen
- Eyelids
- Retroauricular region
- Neck
- Inguinal and anogenital regions

HEENT

Macroglossia
Parotid gland enlargement
Submandibular gland enlargement
Peri-orbital purpura
Raised intraocular pressure may be seen.
Visual and hearing loss may be seen.

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url = http://atlasdermatologico.com.br/disease.jsf?diseaseId=27>

url = http://atlasdermatologico.com.br/disease.jsf?diseaseId=27>

url = http://atlasdermatologico.com.br/disease.jsf?diseaseId=27>

url = http://atlasdermatologico.com.br/disease.jsf?diseaseId=27>

url = http://atlasdermatologico.com.br/disease.jsf?diseaseId=27>

url = http://atlasdermatologico.com.br/disease.jsf?diseaseId=27>

url = http://atlasdermatologico.com.br/disease.jsf?diseaseId=27>

Neck

Neck examination of patients with amyloidosis is usually normal.

Lungs

Hoarseness
Stridor
Dysphagia

Heart

Arrhythmia

Abdomen

Hepatomegaly

Back

Back examination of patients with amyloidosis is usually normal.

Genitourinary

Genitourinary examination of patients with amyloidosis is usually normal.

Neuromuscular

Numbness
Paresthesia
Pain

References

↑ Wechalekar AD, Gillmore JD, Hawkins PN (June 2016). "Systemic amyloidosis". Lancet. 387 (10038): 2641–2654. doi:10.1016/S0140-6736(15)01274-X. PMID 26719234.
↑ Pribitkin E, Friedman O, O'Hara B, Cunnane MF, Levi D, Rosen M, Keane WM, Sataloff RT (December 2003). "Amyloidosis of the upper aerodigestive tract". Laryngoscope. 113 (12): 2095–101. doi:10.1097/00005537-200312000-00007. PMID 14660909.

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[pmid267192344-1] Wechalekar AD, Gillmore JD, Hawkins PN (June 2016). "Systemic amyloidosis". Lancet. 387 (10038): 2641–2654. doi:10.1016/S0140-6736(15)01274-X. PMID 26719234.

[pmid14660909-2] Pribitkin E, Friedman O, O'Hara B, Cunnane MF, Levi D, Rosen M, Keane WM, Sataloff RT (December 2003). "Amyloidosis of the upper aerodigestive tract". Laryngoscope. 113 (12): 2095–101. doi:10.1097/00005537-200312000-00007. PMID 14660909.

[1]

[2]