Lipoma pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]

Overview

Lipomas are mainly characterized by rearrangements of chromosome 12q13q15 with several partner chromosomes in approximately, especially chromosome 3^[1].
Lipomas without 12q13q15 rearrangements frequently show rearrangements of chromosome 6p21.
Several lipoma fusion genes have been identified and the most common is LPP-HMGA2, product of the t(3;12)(q27-q28;q14-a15).

Lipoma is seen as a well-circumscribed yellow mass.

Histopathologic slide of renal angiomyolipoma. Nephrectomy specimen. H & E stain.^[3]
Histopathologic slide of renal angiomyolipoma. Nephrectomy specimen. H & E stain.^[3]
Histopathologic slide of renal angiomyolipoma. Nephrectomy specimen. H & E stain.^[3]
Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. HMB-45 immunostain.^[3]

Lipomas may have following immunohistochemical markers:^[4]

↑ Ida CM, Wang X, Erickson-Johnson MR, Wenger DE, Blute ML, Nascimento AG; et al. (2008). "Primary retroperitoneal lipoma: a soft tissue pathology heresy?: report of a case with classic histologic, cytogenetics, and molecular genetic features". Am J Surg Pathol. 32 (6): 951–4. PMID 18551755.
↑ Image courtesy of Dr Andrew Ryan. Radiopaedia (original file [1]).[http://radiopaedia.org/licence Creative Commons BY-SA-NC
↑ ^3.0 ^3.1 ^3.2 ^3.3 http://librepathology.org/wiki/index.php/Angiomyolipoma
↑ Fletcher, Christopher (2002). Pathology and genetics of tumours of soft tissue and bone. Lyon: IARC Press. ISBN 9283224132.