Adult bronchiolitis causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Hadeel Maksoud M.D.[2]

Overview

Common causes of bronchiolitis include inhalational injury, viral, and drug induced, such as, mineral dusts, diacetyl, RSV and busulfan. Less common causes include heart/lung/kidney transplant, rheumatoid arthritis and ulcerative colitis.

Causes

Life-threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]
Life-threatening causes of adult bronchiolitis include irritant gases such as chlorine and mustard gas.

Common Causes

Adult bronchiolitis may be caused by:

Inhalational injury
- Toxic fumes
- Mineral dusts
- Irritant gases
  - Chlorine, ammonia, mustard gas, welding vapors, paraquat and diacetyl
Post-infectious
- Virus
  - RSV (respiratory syncytial virus)
  - Adenovirus
  - Rhinovirus
  - Measles
  - Mumps
  - Varicella zoster
  - CMV (cytomegalovirus)
  - HIV (human immunodeficiency virus)
- Other pathogens
Drug - induced

Less Common Causes

Less common causes of bronchiolitis include:

Organ transplant (Bronchiolitis obliterans syndrome (BOS))
- Heart
- Lung
- Kidney
Associated conditions
Rare associated conditions
- ARDS (adult respiratory distress syndrome)
- Ataxia telangiectasia
- Lysinuric protein intolerance
- Malignant histiocytosis
- Paraneoplastic pemphigus
- Primary biliary cholangitis
- Ulcerative colitis
- Vasculitis
  - Wegener's granulomatosis (granulomatosis with polyangiitis)
  - Churg-strauss syndrome (eosinophilic granulomatosis with polyangiitis)
Idiopathic
- Cryptogenic bronchiolitis obliterans

Causes by Organ System

Cardiovascular	Heart transplant
Chemical/Poisoning	Toxic fumes, mineral dusts, irritant gases; chlorine, ammonia, mustard gas, welding vapors, paraquat, diacetyl
Dental	No underlying causes
Dermatologic	Sjögren's syndrome, dermatomyositis, paraneoplastic pemphigus
Drug Side Effect	Busulfan, cocaine, gold, nimesulide, penicillamine, papaverine, rituximab, sulfasalazine, sulfamethoxypyridazine
Ear Nose Throat	No underlying causes
Endocrine	No underlying causes
Environmental	No underlying causes
Gastroenterologic	Primary biliary cholangitis, ulcerative colitis
Genetic	Ataxia telangiectasia
Hematologic	No underlying causes
Iatrogenic	No underlying causes
Infectious Disease	RSV (respiratory syncytial virus), adenovirus, rhinovirus, measles, mumps, varicella zoster, CMV (cytomegalovirus), HIV (human immunodeficiency virus), bordetella pertussis, mycoplasma pneumonia, nocardia
Musculoskeletal/Orthopedic	No underlying causes
Neurologic	No underlying causes
Nutritional/Metabolic	Lysinuric protein intolerance
Obstetric/Gynecologic	No underlying causes
Oncologic	Paraneoplastic pemphigus, malignant histiocytosis
Ophthalmologic	No underlying causes
Overdose/Toxicity	Toxic fumes, mineral dusts, irritant gases; chlorine, ammonia, mustard gas, welding vapors, paraquat, diacetyl, busulfan, cocaine, gold, nimesulide, penicillamine, papaverine, rituximab, sulfasalazine, sulfamethoxypyridazine
Psychiatric	No underlying causes
Pulmonary	ARDS (adult respiratory distress syndrome), lung transplant
Renal/Electrolyte	Kidney transplant
Rheumatology/Immunology/Allergy	Wegener's granulomatosis (granulomatosis with polyangiitis), churg-strauss syndrome (eosinophilic granulomatosis with polyangiitis), rheumatoid arthritis, sjögren's syndrome, systemic lupus erythematosus, polymyositis, dermatomyositis
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	Cryptogenic bronchiolitis obliterans

Causes in Alphabetical Order

List the causes of the disease in alphabetical order.

Ammonia
ARDS (adult respiratory distress syndrome)
Adenoviridae
Ataxia telangiectasia
Bordetella pertussis
Busulfan
CMV (cytomegalovirus)
Chlorine gas
Churg-strauss syndrome (eosinophilic granulomatosis with polyangiitis)
Cocaine
Cryptogenic bronchiolitis obliterans
Dermatomyositis
Diacetyl
Gold
HIV (human immunodeficiency virus)
Heart transplantation
Kidney tranplantation
Lung transplantation
Lysinuric protein intolerance
Malignant histiocytosis
Measles
Mineral dusts
Mumps
Mustard gas
Mycoplasma pneumoniae
Nimesulide
Nocardia
Papaverine (sauropus androgynus leaf)
Paraneoplastic pemphigus
Paraquat
Penicillamine
Polymyositis
Primary biliary cholangitis
RSV (respiratory syncytial virus)
Rheumatoid arthritis
Rhinovirus
Rituximab
Sjögren's syndrome
Sulfamethoxypyridazine
Sulfasalazine
Systemic lupus erythematosus
Ulcerative colitis
Varicella zoster
Vasculitis
Wegener's granulomatosis (granulomatosis with polyangiitis)
Welding vapors

References

↑ Hendrick DJ (March 2008). ""Popcorn worker's lung" in Britain in a man making potato crisp flavouring". Thorax. 63 (3): 267–8. doi:10.1136/thx.2007.089607. PMID 18308961.
↑ van Rooy FG, Rooyackers JM, Prokop M, Houba R, Smit LA, Heederik DJ (September 2007). "Bronchiolitis obliterans syndrome in chemical workers producing diacetyl for food flavorings". Am. J. Respir. Crit. Care Med. 176 (5): 498–504. doi:10.1164/rccm.200611-1620OC. PMID 17541015.
↑ Hsiue TR, Guo YL, Chen KW, Chen CW, Lee CH, Chang HY (January 1998). "Dose-response relationship and irreversible obstructive ventilatory defect in patients with consumption of Sauropus androgynus". Chest. 113 (1): 71–6. PMID 9440571.
↑ Lockey JE, Hilbert TJ, Levin LP, Ryan PH, White KL, Borton EK, Rice CH, McKay RT, LeMasters GK (July 2009). "Airway obstruction related to diacetyl exposure at microwave popcorn production facilities". Eur. Respir. J. 34 (1): 63–71. doi:10.1183/09031936.00050808. PMID 19567602.
↑ Harber P, Levine J, Bansal S (October 2009). "How frequently should workplace spirometry screening be performed?: optimization via analytic models". Chest. 136 (4): 1086–1094. doi:10.1378/chest.09-0237. PMID 19411294.
↑ "Obliterative bronchiolitis in workers in a coffee-processing facility - Texas, 2008-2012". MMWR Morb. Mortal. Wkly. Rep. 62 (16): 305–7. April 2013. PMC 4604960. PMID 23615673.
↑ Ghanei M, Tazelaar HD, Chilosi M, Harandi AA, Peyman M, Akbari HM, Shamsaei H, Bahadori M, Aslani J, Mohammadi A (June 2008). "An international collaborative pathologic study of surgical lung biopsies from mustard gas-exposed patients". Respir Med. 102 (6): 825–30. doi:10.1016/j.rmed.2008.01.016. PMID 18339530.
↑ King MS, Eisenberg R, Newman JH, Tolle JJ, Harrell FE, Nian H, Ninan M, Lambright ES, Sheller JR, Johnson JE, Miller RF (July 2011). "Constrictive bronchiolitis in soldiers returning from Iraq and Afghanistan". N. Engl. J. Med. 365 (3): 222–30. doi:10.1056/NEJMoa1101388. PMC 3296566. PMID 21774710.

[pmid18308961-1] Hendrick DJ (March 2008). ""Popcorn worker's lung" in Britain in a man making potato crisp flavouring". Thorax. 63 (3): 267–8. doi:10.1136/thx.2007.089607. PMID 18308961.

[pmid17541015-2] van Rooy FG, Rooyackers JM, Prokop M, Houba R, Smit LA, Heederik DJ (September 2007). "Bronchiolitis obliterans syndrome in chemical workers producing diacetyl for food flavorings". Am. J. Respir. Crit. Care Med. 176 (5): 498–504. doi:10.1164/rccm.200611-1620OC. PMID 17541015.

[pmid9440571-3] Hsiue TR, Guo YL, Chen KW, Chen CW, Lee CH, Chang HY (January 1998). "Dose-response relationship and irreversible obstructive ventilatory defect in patients with consumption of Sauropus androgynus". Chest. 113 (1): 71–6. PMID 9440571.

[pmid19567602-4] Lockey JE, Hilbert TJ, Levin LP, Ryan PH, White KL, Borton EK, Rice CH, McKay RT, LeMasters GK (July 2009). "Airway obstruction related to diacetyl exposure at microwave popcorn production facilities". Eur. Respir. J. 34 (1): 63–71. doi:10.1183/09031936.00050808. PMID 19567602.

[pmid19411294-5] Harber P, Levine J, Bansal S (October 2009). "How frequently should workplace spirometry screening be performed?: optimization via analytic models". Chest. 136 (4): 1086–1094. doi:10.1378/chest.09-0237. PMID 19411294.

[pmid23615673-6] "Obliterative bronchiolitis in workers in a coffee-processing facility - Texas, 2008-2012". MMWR Morb. Mortal. Wkly. Rep. 62 (16): 305–7. April 2013. PMC 4604960. PMID 23615673.

[pmid18339530-7] Ghanei M, Tazelaar HD, Chilosi M, Harandi AA, Peyman M, Akbari HM, Shamsaei H, Bahadori M, Aslani J, Mohammadi A (June 2008). "An international collaborative pathologic study of surgical lung biopsies from mustard gas-exposed patients". Respir Med. 102 (6): 825–30. doi:10.1016/j.rmed.2008.01.016. PMID 18339530.

[pmid21774710-8] King MS, Eisenberg R, Newman JH, Tolle JJ, Harrell FE, Nian H, Ninan M, Lambright ES, Sheller JR, Johnson JE, Miller RF (July 2011). "Constrictive bronchiolitis in soldiers returning from Iraq and Afghanistan". N. Engl. J. Med. 365 (3): 222–30. doi:10.1056/NEJMoa1101388. PMC 3296566. PMID 21774710.

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