PURSUIT risk score

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Definition and History

The PURSUIT (Platelet glycoprotein IIb/IIIa in Unstable angina: Receptor Suppression Using Integrilin Therapy) risk score was developed in a randomized clinical trial which recruited 9,461 patients and compared eptifibatide (Integrilin) to placebo in the management of Unstable Angina (UA) or Non-ST elevation Myocardial Infarction (NSTEMI).

Function

  • By using multivariate regression analysis, the investigators established seven risk predictors for death and myocardial infarction (MI) in patients with acute coronary syndromes.
  • Five of these risk factors were then combined into a scoring system:
    • Higher age
    • Sex
    • Worst Canadian Cardiovascular Society (CCS) class of angina
    • Signs of heart failure
    • ST-segment depression on the index ECG
  • Each of these elements is scored accordingly, resulting in a score ranging 1 - 18.
PURSUIT Risk Score
Elements Entry Score
Age
  • 50
  • 60
  • 70
  • 80
  • 8
  • 9
  • 11
  • 12
Sex
  • Male
  • Female
  • 1
  • 0
Worst CCS class past 6 weeks
  • No angina/CCS I/II
  • CCS III/IV
  • 0
  • 2
Signs of heart failure
  • 2
ST depression on ECG
  • 1

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