Tetralogy of fallot causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editors-In-Chief: Fahimeh Shojaei, M.D., Priyamvada Singh, M.B.B.S. [2], Keri Shafer, M.D. [3]; Assistant Editor-In-Chief: Kristin Feeney, B.S. [4]

Overview

Common causes of tetralogy of Fallot may include: Alcoholism in the mother, diabetes, pregnancy after the age of 40, rubella or other viral illnesses during pregnancy, phenylketonuria (PKU) in the mother, fetal hydantoin syndrome, and fetal carbamazepine syndrome.

Common causes of tetralogy of Fallot may include:

Less common causes of tetralogy of Fallot may include:

Genetic causes of tetralogy of Fallot may include:

There is a high incidence of chromosomal disorders in children with tetralogy of Fallot.^[1]^[2]
Tetralogy of Fallot is associated with:

Down syndrome
DiGeorge syndrome (a 22q11.2 deletion, a condition associated with heart defects, hypocalcemia, and immune deficiency) A gene polymorphism at the methylenetetrahydrofolate reductase (MTHFR) region has been associated with tetralogy of Fallot.

↑ Marinho C, Alho I, Guerra A, Rego C, Areias J, Bicho M. The methylenetetrahydrofolate reductase gene variant (C677T) as a susceptibility gene for tetralogy of Fallot. Rev Port Cardiol. Jul-Aug 2009;28(7-8):809-12.
↑ Lee CN, Su YN, Cheng WF, Lin MT, Wang JK, Wu MH, et al. Association of the C677T methylenetetrahydrofolate reductase mutation with congenital heart diseases. Acta Obstet Gynecol Scand. Dec 2005;84(12):1134-40.