Sick sinus syndrome historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Sick sinus syndrome was first discribed by Dr. Keith and Dr. Flack, in 1907. In 2015, MYH6 gene mutations were first implicated in the pathogenesis of sick sinus syndrome.
Historical Perspective
Discovery
- Sick sinus syndrome was first discribed by Dr. Keith and Dr. Flack, in 1907.[1]
- In 2015, MYH6 gene mutations were first implicated in the pathogenesis of sick sinus syndrome.[2]
Landmark Events in the Development of Treatment Strategies
Impact on Cultural History
References
- ↑ Keith A, Flack M (April 1907). "The Form and Nature of the Muscular Connections between the Primary Divisions of the Vertebrate Heart". J Anat Physiol. 41 (Pt 3): 172–89. PMC 1289112. PMID 17232727.
- ↑ Ishikawa T, Jou CJ, Nogami A, Kowase S, Arrington CB, Barnett SM, Harrell DT, Arimura T, Tsuji Y, Kimura A, Makita N (April 2015). "Novel mutation in the α-myosin heavy chain gene is associated with sick sinus syndrome". Circ Arrhythm Electrophysiol. 8 (2): 400–8. doi:10.1161/CIRCEP.114.002534. PMID 25717017.