Sick sinus syndrome overview

Sick sinus syndrome Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]

Historical Perspective

Sick sinus syndrome was first discribed by Dr. Keith and Dr. Flack, in 1907. In 2015, MYH6 gene mutations were first implicated in the pathogenesis of sick sinus syndrome.

Pathophysiology

Sick sinus syndrome occurs as an improperly propagated signal from the sinoatrial (SA) node. Age-dependent progressive fibrosis of the sinus nodal tissue and Remodeling of sinuatrial node are the potential mechanisms of this abnormally formed signal propagation. MYH6 gene may also be involved in the pathogenesis of this condition.