Lev's disease

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Lev's disease is an acquired complete heart block due to idiopathic fibrosis and calcification of the electrical conduction system of the heart. Lev's disease is most commonly seen in the elderly, and is often described as senile degeneration of the conduction system.

One form has been associated with SCN5A.^[1]

Historical Perspective

It was described independently by two researchers in 1964,^[2]^[3] but the condition is generally called after Lev.

Pathophysiology

Associated Conditions

Stokes-Adams attacks can be precipitated by this condition. These involve a temporary loss of consciousness due to ventricular fibrillation or asystole.^[4]

Related Chapters

Heart block

References

↑ Schott JJ, Alshinawi C, Kyndt F; et al. (1999). "Cardiac conduction defects associate with mutations in SCN5A". Nat. Genet. 23 (1): 20–1. doi:10.1038/12618. PMID 10471492.
↑ Lev M. Anatomic basis for atrioventricular block. Am J Med 1964;37:742-8. PMID 14237429.
↑ Lenegre J. Etiology and pathology of bilateral bundle branch block in relation to complete heart block. Prog Cardiovasc Dis 1964;6:409-444. PMID 14153648.
↑ Carius BM, Long B, Schauer S (2019). "Lev's Syndrome: A rare case of progressive cardiac conduction disorder presenting to the emergency department". Am J Emerg Med. 37 (5): 1006.e1–1006.e4. doi:10.1016/j.ajem.2019.01.054. PMID 30723001.

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[pmid10471492-1] Schott JJ, Alshinawi C, Kyndt F; et al. (1999). "Cardiac conduction defects associate with mutations in SCN5A". Nat. Genet. 23 (1): 20–1. doi:10.1038/12618. PMID 10471492.

[2] Lev M. Anatomic basis for atrioventricular block. Am J Med 1964;37:742-8. PMID 14237429.

[3] Lenegre J. Etiology and pathology of bilateral bundle branch block in relation to complete heart block. Prog Cardiovasc Dis 1964;6:409-444. PMID 14153648.

[pmid30723001-4] Carius BM, Long B, Schauer S (2019). "Lev's Syndrome: A rare case of progressive cardiac conduction disorder presenting to the emergency department". Am J Emerg Med. 37 (5): 1006.e1–1006.e4. doi:10.1016/j.ajem.2019.01.054. PMID 30723001.

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