Short QT syndrome epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Since the syndrome was first described in 2000, < 30 cases have been identified.
Age
The median age of presentation is 30 years but ranges from just weeks to the sixth decade of life. According to a few studies prevalence of Short QT interval is 0.02 to 0.1% in adults and it is believed to be 0.05% in the pediatric population[1].
- Inability to identify the risks associated with short QT interval has led to failure in knowing precise prevalence in adults but it appears to be less than 2 percent if a cut off of 360 milliseconds is used. Studies with large cohorts have made attempts to identify how frequently could SQTS occur in the general population.
- In a Japanese cohort of 114,334 patients with ECGs stored in an electronic database, 0.37 percent were found to have short QTc intervals (≤357 milliseconds in males, ≤364 milliseconds in females) [2].
- In an American cohort of 46,129 healthy volunteers (53 percent female), 2 percent had a QTc interval ≤360 milliseconds [3].
- In a Swiss cohort of 41,767 army conscripts (99.6 percent male, mean age 19 years), 1 percent had a short QTc interval (<347 milliseconds), and 0.02 percent had a very short QTc interval (<320 milliseconds) [4].
- In a Finnish cohort of 10,822 middle-aged (mean 44 years) patients, 0.4 percent had a short QTc interval (<340 milliseconds), and 0.1 percent had a very short QTc interval (<320 milliseconds) [5]
References
- ↑ Guerrier K, Kwiatkowski D, Czosek RJ, Spar DS, Anderson JB, Knilans TK (2015). "Short QT Interval Prevalence and Clinical Outcomes in a Pediatric Population". Circ Arrhythm Electrophysiol. 8 (6): 1460–4. doi:10.1161/CIRCEP.115.003256. PMID 26386018.
- ↑ Miyamoto A, Hayashi H, Yoshino T, Kawaguchi T, Taniguchi A, Itoh H; et al. (2012). "Clinical and electrocardiographic characteristics of patients with short QT interval in a large hospital-based population". Heart Rhythm. 9 (1): 66–74. doi:10.1016/j.hrthm.2011.08.016. PMID 21855519.
- ↑ Mason JW, Ramseth DJ, Chanter DO, Moon TE, Goodman DB, Mendzelevski B (2007). "Electrocardiographic reference ranges derived from 79,743 ambulatory subjects". J Electrocardiol. 40 (3): 228–34. doi:10.1016/j.jelectrocard.2006.09.003. PMID 17276451.
- ↑ Kobza R, Roos M, Niggli B, Abächerli R, Lupi GA, Frey F; et al. (2009). "Prevalence of long and short QT in a young population of 41,767 predominantly male Swiss conscripts". Heart Rhythm. 6 (5): 652–7. doi:10.1016/j.hrthm.2009.01.009. PMID 19303371.
- ↑ Anttonen O, Junttila MJ, Rissanen H, Reunanen A, Viitasalo M, Huikuri HV (2007). "Prevalence and prognostic significance of short QT interval in a middle-aged Finnish population". Circulation. 116 (7): 714–20. doi:10.1161/CIRCULATIONAHA.106.676551. PMID 17679619.