Sandbox:ab

Thank you for your great work! There are only a few comments which may help you to improve the page.

You could follow abc format greatly

• I think Dr. Gibson asked us not to make bold any part of the passage, if I am not mistaken.
• Some grammatical mistakes:

In historical perspective:

• reffered :refereed
• struk down : struck
• centuary: century
• blockage of cerebral artery: blockage of a cerebral artery.
• Mao et. al. in his study first reported: Mao et al., in his study,(comma)
• 214 Covid-19 positive hospitalized patients. with COVID-19 in Wuhan: 214 Covid-19 positive hospitalized patients with COVID-19 in Wuhan (dot)
• Yaghi et. al. : Yaghi et al.
• incidence of 0.9% : the incidence of 0.9%

Pathophysiology:

• renin-angiotensin system which: renin-angiotensin system, which (comma)
• but the beta coronavirues : but the beta coronaviruses
• It,therefore, has infection: It, therefore, has an infection
• The detection of virus: The detection of the virus
• It attaches with the ACE II receptors: it attaches to the ACE II receptors.

• I think in the causes section, it would be better to mention what are the reasons that stroke-related to COVID-19 happens. For instance, in cardiogenic shock related to COVID reasons includes: MI, MIS-C, Worsening of previous left ventricular failure due to COVID-19, etc.

• can have similar presentation: can have similar presentations (S)
• I think for DDX section it might be better if you make use of a table

• Mostly Cryptogenic stroke seen in COVID-19 patients: Mostly Cryptogenic stroke was seen in COVID-19 patients

• I recommend you to make use of Grammarly application to lower your grammatical mistakes

• In Laboratory Findings and Medical Therapy parts: There was some extra symbols such as *

In patients older than 75 years of age with clinical ASCVD, it is reasonable to initiate moderate or high-intensity statin therapy after evaluation of the potential for ASCVD risk reduction, adverse effects, and drug interactions.*

• I think the ultrasound section needs a reference
• This sentence did not have any reference too :

"Aspirin should not substitute IV alteplase or mechanical thrombectomy in patients eligible for these therapies." It would be better if you could add references to Primary Prevention and Secendary Prevention as well.

Thank you