COVID-19 other diagnostic studies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]
Overview
Research laboratories have used isolation methods, electron microscopy, serology and PCR-based assays to diagnose coronavirus infections for surveillance studies.
Other Diagnostic Studies
Specific laboratory tests may include:
- Virus isolation in cell culture.
- Polymerase chain reaction (PCR) assays that are more practical and available commercially.
- Serological testing for antibodies to human coronaviruses.[1] [2]
Nose and throat swabs are the best specimens for detecting common human coronaviruses. Serological testing requires the collection of blood specimens.
Gallery
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SEM reveals the “rosette-like” appearance of the matured coronavirus particles. From Public Health Image Library (PHIL). [3]
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TEM revealed the presence of a number of infectious bronchitis virus (IBV) virions. From Public Health Image Library (PHIL). [3]
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Scanning electron micrograph reveals the prolific exportation of virus particles at the pseudopodial and cell surfaces. From Public Health Image Library (PHIL). [3]
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Scanning electron micrograph reveals the prolific exportation of virus particles at the pseudopodial and cell surfaces. From Public Health Image Library (PHIL). [3]
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TEM from a tissue culture isolate, revealing numbers of severe acute respiratory virus (SARS) virions. From Public Health Image Library (PHIL). [3]
References
- ↑ Udugama B, Kadhiresan P, Kozlowski HN, Malekjahani A, Osborne M, Li VYC; et al. (2020). "Diagnosing COVID-19: The Disease and Tools for Detection". ACS Nano. 14 (4): 3822–3835. doi:10.1021/acsnano.0c02624. PMC 7144809 Check
|pmc=
value (help). PMID 32223179 Check|pmid=
value (help). - ↑ Tang YW, Schmitz JE, Persing DH, Stratton CW (2020). "Laboratory Diagnosis of COVID-19: Current Issues and Challenges". J Clin Microbiol. 58 (6). doi:10.1128/JCM.00512-20. PMC 7269383 Check
|pmc=
value (help). PMID 32245835 Check|pmid=
value (help). - ↑ 3.0 3.1 3.2 3.3 3.4 "Public Health Image Library (PHIL)".