Anemia of prematurity differential diagnosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Asra Firdous, M.B.B.S.[2]
Overview
Anemia of prematurity should be differentiated from anemia due to increased red blood cell destruction, increased blood loss, and decreased red blood cell production. It should also be differentiated from other causes of normocytic normochromic anemia.
Differential Diagnosis
Anemia of prematurity should be differentiated from anemia due to increased red blood cell destruction, increased blood loss, and decreased red blood cell production[1]. Anemia of prematurity should also be differentiated from other causes of normocytic normochromic anemia.
Increased RBC destruction
Anemia of prematurity should be differentiated from anemia due to increased red blood cell destruction:
- Hemolytic anemias
- Congenital fetal infections
- Sepsis
- Disseminated intravascular coagulation
Decrease RBC production
Anemia of prematurity should be differentiated from anemia due to decreased red blood cell production:
- Congenital fetal infections
- Diamond-Blackfan anemia
- Aplastic anemia
- Bone marrow infiltration
- Drug-induced anemia
- Iron deficiency
- Folate and Vitamin B12 deficiency
- Vitamin E deficiency
Increase blood loss
Anemia of prematurity should be differentiated from anemia due to increased blood loss: