Sandbox MWH

Year	Discovery
1877	First-ever description of narcolepsy in the medical literature
1880	Gelineau named the disorder “narcolepsy”
1902	Loewenfeld first coined the term “cataplexy”
1935	First-ever use of amphetamines in the treatment of narcolepsy
1960	Description of Sleep Onset REM in patients with narcolepsy
1970	Multiple Latency Test description
1973	First-ever report of narcolepsy in a canine
1983	Association of HLA-DR2 with narcolepsy
1992	Association of HLA-DQB1*0602 with narcolepsy
1998	Hypocretins (orexins) and their receptors identification
2000	Association between Human narcolepsy and hypocretin deficiency

Table 1: A few milestones in narcolepsy research and therapy 1877 First description in the medical literature (100) 1880 Gelineau called the disorder “narcolepsy” (28) 1902 Loewenfeld coined the term “cataplexy” (53) 1935 First use of amphetamines in the treatment of narcolepsy (87) 1960 Description of Sleep Onset REM periods in a narcoleptic subject (99) 1970 Description of the Multiple Latency Test (15, 90) 1973 First report of a narcoleptic dog (47, 72) 1983 Association of narcolepsy with HLA-DR2 (37) 1985 Monoaminergic and cholinergic imbalance in narcolepsy (7, 80) 1992 Association of narcolepsy with HLA-DQB1*0602 (56, 63) 1998 Identification of hypocretins/orexins and their receptors (18, 93) 1999 Hypocretin mutations cause narcolepsy in mice and dogs (16, 51) 2000 Human narcolepsy is also associated with an hypocretin deficiency (81)