Turner syndrome historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Akash Daswaney, M.B.B.S[2]
Overview
Turner syndrome was first described in 1938 by Henry Turner when he noticed a triad of short stature, sexual infantilism, cubitus valgus and pterygium colli. Other scientists went to to discover the pathophysiology of the 45 XO karyotype and the presence of streaked ovaries.
Historical Perspective
- Turner syndrome was first described by Henry Turner, an Oklahoma endocrinologist in 1938 as a patient with short stature, sexual infantilism, cubitus valgus and pterygium colli. "Turner Syndrome - StatPearls - NCBI Bookshelf".
- Ulrich (in 1930) and Bonnevie (in 1934) described similar findings in a young girl and mouse.
- Ovarian failure and streaked gonads were noted in 1944 by Henry Silver and Kaiser who found elevated gonadotrophins in a 32 month old child. "OVARIAN AGENESIS (CONGENITAL APLASTIC OVARIES) IN CHILDREN | JAMA Pediatrics | JAMA Network".
- C.E Ford et al first described the pathophysiology of 45 XO in 1959 at Harwell, Oxfordshire and Guy's Hospital in London.[2] It was found in a 14-year-old girl with signs of Turner syndrome. [1]
References
- ↑ Lowenstein EJ, Kim KH, Glick SA (2004). "Turner's syndrome in dermatology". J Am Acad Dermatol. 50 (5): 767–76. doi:10.1016/j.jaad.2003.07.031. PMID 15097963.