Sandbox:Marufa Marium

Overview

Von Willebrand’s Disease:

Historical Perspective

Von Willebrand’s Disease(vWD) was first discovered by Erik Adolf von Willebrand, a Finnish Physician, in 1926, in a Swedish-language article “Hereditär pseudohemofili” ("Hereditary pseudohemophilia") after assessing a 5 year-old Finnish Girl and 66 members of her family from 1924-1926. In 1957, decreased level of a plasma factor ‘ Factor ⅷ later called ‘Von Willebrand factor’ were first identified in the pathogenesis of Von Willebrand’s Disease.PMID: 24978322

In early 1970s Ristocetin was used to diagnose vWD after inducing platelet aggregation. Later immunoprecipitation techniques were used to understand vWD and it’s varieties. 

Classification

vWD may be classified according to Hereditary and Aquired causes. vWD is sub-classified according to Hereditary in four types.

• Type 1
• Type 2: Type 2 is further divided into 4 subtypes: 2A, 2B, 2M, 2N
• Type 3
• Pseudo or platelet-type