Tricuspid atresia causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor-In-Chief:;Sara Zand, M.D.[2] Keri Shafer, M.D. [3] Priyamvada Singh, MBBS [4]; Assistant Editor-In-Chief: Kristin Feeney, B.S. [5]

Overview

• Disruption tricuspid valvogenesis due to mutation in some genes include:
• A missense mutation in RASA1 that is responsible for the regulation of Ras/ERK cascade.
• A missense mutation in NFATC1 which downregulates the Ras/ERK pathway.
• Familial recurrence of tricuspid atresia is rare.
• Few cases of an autosomal recessive pattern of inheritance are reported.