Cyanosis in newborns
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ifeoma Anaya, M.D.[2]
Synonyms and keywords:
Overview
Cyanosis is coined from the word kuaneos which is greek for dark blue. It is classified into two major types: peripheral and central cyanosis. Cyanosis results when there is an increase in the absolute concentration of deoxygenated hemoglobin to a level of 3-5g/dl. A systematic way of classifying the common causes of cyanosis in newborns is by using the ABC which stands for Airway, Breathing, and Circulation. Congenital heart diseases (CHD) affecting 8-9 per 1000 live births and Persistent pulmonary hypertension of the newborn are the common causes of newborn cyanosis. In older kids, respiratory diseases tend to be more common. Common risk factors in the development of cyanosis in newborns are evident in the pregnancy and labor period. Complications and prognosis are dependent on the actual cause of the cyanosis, prompt recognition, and administration of treatment modalities with appropriate referral to the ideal hospital setting equipped to manage the diagnosis. The primary symptom is the bluish/dark colored lips, mucous membrane, and/or hands and feet. Breathing difficulties such as nasal flaring, chest retractions. Exam findings include lethargy, conjuctival injection, features of shock, tachypnea. Laboratory findings include a Complete blood count and differentials showing ↑Packed cell volume(PCV) suggesting polycythemia, ↑White cell count (Septicemia). Although seldom helpful, an ECG may aid in the diagnosis of arrhythmias and dextrocardias.
Historical Perspective
- Cyanosis is coined from the word kuaneos which is greek for dark blue. This is as a result of the bluish discoloration of the skin or mucous membranes depending on etiology. [1]
Classification
- Cyanosis is classified into two major types:[2]
- Peripheral Cyanosis (acrocyanosis) which is located on the hands and feet. It is mostly physiological and relatively common.
- Central cyanosis which is considered to be pathological and requiring immediate evaluation until proven otherwise.
Pathophysiology
- Central yanosis results when there is an increase in the absolute concentration of deoxygenated hemoglobin to a level of 3-5g/dl. Deoxygenated hemoglobin is dusky blue or purple which gives rise to the discoloration seen in skin and mucous membranes compared to bright red oxyhemoglobin.[1]
- Oxygen is transported in blood predominantly as bound to hemoglobin while an insignificant amount is transported dissolved in plasma. Sufficient tissue perfusion is largely dependent on the concentration of saturated hemoglobin.
- In the setting of high hemoglobin concentrations (normal relative polycythemia, 14-20g/dl) seen in normal infants, cyanosis becomes apparent at higher PaO2 (partial pressure of oxygen) compared to the setting of severe anemia where a much lower PaO2 would result in clinically recognizable cyanosis due to very low hemoglobin concentration. Therefore, cyanosis is a factor of the concentration of deoxygenated hemoglobin and not merely oxygen saturation. For example, a neonate with a hemoglobin concentration of 24g/dl exhibits signs of central cyanosis at 88% arterial saturation (SaO2) while cyanosis is not clinically obvious in an anemic infant until SaO2 falls to about 62%. [1] [3]
- Fetal and adult hemoglobin possess different capabilities of oxygen binding. If a newborn has mostly adult hemoglobin, cyanosis would be observed at a higher PaO2 of 42-53mmHg corresponding to SaO2 of 75%-85% compared to predominantly fetal hemoglobin(PaO2 of 32-42mmHg); infants have varied proportions of adult and fetal hemoglobin. Therefore, a serious reduction in PaO2 would have set in before cyanosis becomes apparent in a newborn with high levels of fetal hemoglobin, a setting that shifts the oxygen dissociation curve to the left. [3]
- Several changes occur in the newborn as soon as the first breath is taken. Blood flow resistance decreases in the pulmonary vasculature as a result of the increase in oxygen tension; this increase in oxygen tension and pulmonary circulation causes functional closure of the patent ductus arteriosus. Also, the foramen ovale closes from raised left atrial pressures. The events leading to the closures of these shunts invariably abolishes the right-to-left shunts of the fetal circulation. The first breath also causes a net absorption of the fluid from the respiratory system which expands the lungs and in turn initiates gaseous exchange. Furthermore, removal of the low-pressure placental bed causes an increase in blood flow resistance of the systemic vasculature. These are the normal physiological changes observed in the normal neonate after birth. [1]
- Deviations from these can result in pathological conditions requiring immediate interventions; infants, especially those born prematurely will require medical assistance to make this phenomenal transition. [4]
- In peripheral cyanosis, there is normal SaO2 with an increase in oxygen uptake by tissues resulting in a large arteriovenous difference in the venous aspect of the capillaries. Vasoconstriction could also be a cause. This type of cyanosis is seen majorly at the extremities.
Causes
- A systematic way of classifying the common causes of cyanosis in newborns is by using the ABC which stands for Airway, Breathing, and Circulation.
| Causes of Cyanois in newborns | |||||||||||||||||||||||||||||||||||||||||||||||
| Airway | Breathing | Circulation | |||||||||||||||||||||||||||||||||||||||||||||
| • Cystic hygroma • Hemangioma • Choanal atresia • Micrognathia • Laryngomalacia • Tracheal stenosis • Vascular rings • Vocal cord paralysis • Pierre-Robin sequence | • Phrenic nerve palsy • Congenital diaphragmatic hernia • Perinatal asphyxia • Pulmonary hypoplasia • Inborn errors of metabolism • Central nervous system and muscle congenital anomalies • Neonatal sepsis • Neonatal botulism • Congenital cystic adenomatoid malformation • Pneumonia | • Congenital heart diseases Tetralogy of Fallot Tricuspid atresia Pulmonary atresia Pulmonary stenosis Ebstein's anomaly Transposition of great arteries Hypoplastic left heart syndrome Atrioventricular canal defect Total anomalous pulmonary venous return • Anemia • Methemoglobinemia • Polycythemia • Persistent pulmonary hypertension | |||||||||||||||||||||||||||||||||||||||||||||
Epidemiology and Demographics
- Congenital heart diseases (CHD) affecting 8-9 per 1000 live births and Persistent pulmonary hypertension of the newborn are the common causes of newborn cyanosis. In older kids, respiratory diseases tend to be more common. [5] [6]
- Tetralogy of Fallot (TOF) followed closely by the Transposition of Great Arteries (TGA) are the commonest causes of CHD.[6]
Age
- Patients of all age groups may develop cyanosis depending on the etiology.
- It is however commonly observed among newborns due to the peculiarities of birth and the changes that occur during the transition from fetal to neonatal life or due to congenital or acquired disorders.
Gender
- No documented eveidence of gender predilection.
Race
- There is no racial predilection for cyanosis in newborns.
Risk Factors
- Common risk factors in the development of cyanosis in newborns are evident in the pregnancy and labor period. [7]
- Pregnancy-related risk factors are:
- Advanced age of the mother
- Pregnancy-induced hypertension
- Gestational diabetes
- Intake of Lithium (Ebstein's anomaly)
- Oligohydramnios
- Polyhydramnios
- Labor and birth-related risk factors are:
- Cesarean section
- Preterm/prematurity
- Use of anesthetic drugs and/or sedatives
- Prolonged Rupture of Membrane (PROM)
- Meconium aspiration
- Difficult/assisted vaginal delivery
Natural History, Complications and Prognosis
- Potential complications seen in these patients can include:
- Stroke
- Sudden Cardiac Arrest
- Recurrent and/or severe respiratory tract infections in infants with unrepaired heart defects
- Developmental delays ranging from motor to cognitive
- Various forms of disabilities
- Arrhythmias
- Heart failure
- Complications and prognosis are dependent on the actual cause of the cyanosis, prompt recognition, and administration of treatment modalities with appropriate referral to the ideal hospital setting equipped to manage the diagnosis.
- Mortality is high in newborns with critical CHD however, there has been an encouraging improvement in one-year survival to 75% following advances in treatment. 69% of these babies can survive to the age of 18 years. [1][6]
Diagnosis
Symptoms
- Primary symptom is the bluish/dark colored lips, mucous membrane, and/or hands and feet.
- Others are symptoms related to the actual cause of cyanosis which includes the following:
- Breathing difficulties such as:
- Nasal flaring
- Chest retractions
- Fast breathing
- Slow breathing
- Irregular breathing
- History of momentary cessations of breathing
- Pausing/excessive sweating or crying while feeding
- Small volume of feeds
- Small for age/poor weight gain
- Large for age
- Fixed/immobile arms suggesting paralysis from birth trauma
- Enlarged or enlarging head size with\without scalp injuries from a difficult delivery
- Hypo/hyperactive child
- Breathing difficulties such as:
Physical Examination
- Patients usually appear cyanosis.
- Other examination findings relates to the underlying cause of cyanosis which may include:
- Lethargy
- Conjuctival injection
- Features of shock
- Tachypnea
- Periodic breathing
- Apneic spells
- Use of accessory muscles of respiration
- Flaring of the alar nasa
- Insert a tube or catheter if high index of suspicion for Choanal atresia
- Tachycardia
- Abnormal heart sounds/murmurs
- Weak peripheral pulses especially femoral
- Fine crackles in lower lung fields
- Hepatomegaly
- Scaphoid abdomen(in diaphragmatic hernia)
- Erb's paralysis
- Scalp injuries
- Seizures
Laboratory Findings
- Complete blood count and differentials
- ↑Packed cell volume(PCV)- Polycythemia
- ↑White cell count- Septicemia
- Complete metabolic panel- electrolyte derangements (metabolic acidosis)
- Serum glucose- hypo or hyperglycemia
- Hyperoxia Test- differentiates pulmonary from a cardiovascular cause. An increase in PaO2 to 100mmHg or more after administering 100% oxygen suggests a pulmonary etiology. Currently not necessary due to the wide availability of echocardiography.
- Arterial Blood Gases (ABGs)
- PaCO2, ↑ suggests hypoventilation of either CNS or pulmonary etiology, heart failure,
- PaO2, ↓ confirms cyanosis
- PH, a ↓ suggests hypoxemia, sepsis
- ↔ PaO2, ↓SaO2, the color of blood described as 'chocolate-brown, Methemoglobinemia
Electrocardiogram
- It is seldom helpful however, an ECG may be helpful in the diagnosis of arrhythmias and dextrocardias. It detects abnormal axis deviations such as a left axis deviation seen in Tricuspid atresia due to left ventricular hypertrophy. It could give a normal reading in very serious heart defects like TGA. [1]
X-ray
There are no x-ray findings associated with [disease name].
OR
An x-ray may be helpful in the diagnosis of [disease name]. Findings on an x-ray suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].
OR
There are no x-ray findings associated with [disease name]. However, an x-ray may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].
Echocardiography or Ultrasound
There are no echocardiography/ultrasound findings associated with [disease name].
OR
Echocardiography/ultrasound may be helpful in the diagnosis of [disease name]. Findings on an echocardiography/ultrasound suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].
OR
There are no echocardiography/ultrasound findings associated with [disease name]. However, an echocardiography/ultrasound may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].
CT scan
There are no CT scan findings associated with [disease name].
OR
[Location] CT scan may be helpful in the diagnosis of [disease name]. Findings on CT scan suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].
OR
There are no CT scan findings associated with [disease name]. However, a CT scan may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].
MRI
There are no MRI findings associated with [disease name].
OR
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].
OR
There are no MRI findings associated with [disease name]. However, an MRI may be helpful in the diagnosis of complications of [disease name], which include [complications 1], [complication 2], and [complication 3].
Other Imaging Findings
There are no other imaging findings associated with [disease name].
OR
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].
Other Diagnostic Studies
- [Disease name] may also be diagnosed using [diagnostic study name].
- Findings on [diagnostic study name] include [finding 1], [finding 2], and [finding 3].
Treatment
Medical Therapy
- There is no treatment for [disease name]; the mainstay of therapy is supportive care.
- The mainstay of therapy for [disease name] is [medical therapy 1] and [medical therapy 2].
- [Medical therapy 1] acts by [mechanism of action 1].
- Response to [medical therapy 1] can be monitored with [test/physical finding/imaging] every [frequency/duration].
Surgery
- Surgery is the mainstay of therapy for [disease name].
- [Surgical procedure] in conjunction with [chemotherapy/radiation] is the most common approach to the treatment of [disease name].
- [Surgical procedure] can only be performed for patients with [disease stage] [disease name].
Prevention
- Prevention of cyanosis in the neonatal period can be challenging as some of its causes would have been prevalent in-utero before the birth of the child while others occur during the actual labor and birthing process.
- The following preventive measures can be adopted:
- Pre conceptual counseling for expectant mothers especially women who are above the age of 35 years.
- Routine prenatal and postnatal care for early detection of congenital anomalies and adequate preparedness for its management during pregnancy, labor, and delivery.
- Early detection and management of gestational diabetes and pregnancy-induced hypertension.
- Counsel parents of kids with congenital malformations on the risk of having another child with the same or similar deformities.
- Prophylaxis against Respiratory syncytial virus(RSV).
- Follow up for polycythemia, excessive dehydration, and iron-deficiency anemia.[6]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Steinhorn RH (2008). "Evaluation and management of the cyanotic neonate". Clin Pediatr Emerg Med. 9 (3): 169–175. doi:10.1016/j.cpem.2008.06.006. PMC 2598396. PMID 19727322.
- ↑ Izraelit A, Ten V, Krishnamurthy G, Ratner V (2011). "Neonatal cyanosis: diagnostic and management challenges". ISRN Pediatr. 2011: 175931. doi:10.5402/2011/175931. PMC 3317242. PMID 22482063.
- ↑ 3.0 3.1 Lees MH, King DH (1987). "Cyanosis in the newborn". Pediatr Rev. 9 (2): 36–42. doi:10.1542/pir.9-2-36. PMID 3332361.
- ↑ Hooper SB, Polglase GR, Roehr CC (2015). "Cardiopulmonary changes with aeration of the newborn lung". Paediatr Respir Rev. 16 (3): 147–50. doi:10.1016/j.prrv.2015.03.003. PMC 4526381. PMID 25870083.
- ↑ https://pediatriccare.solutions.aap.org/chapter.aspx?sectionid=108722941&bookid=1626
- ↑ 6.0 6.1 6.2 6.3 "StatPearls". 2020. PMID 29763177.
- ↑ https://learn.pediatrics.ubc.ca/body-systems/neonate/approach-to-neonatal-cyanosis/