Thrombophilia resident survival guide
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anahita Deylamsalehi, M.D.[2]
Synonyms and keywords:
Overview
Thrombophilia is defined as a predilection for clot formation (thrombosis). It could be inherited or acquired, nevertheless most of the time thrombophilia is due to an interplay between both inherited and acquired factors. This clot formation tendency can lead to venous thrombus formation and subsequent conditions such as pulmonary embolism, deep venous thrombosis, pregnancy loss and stroke.
Causes
Life Threatening Causes
Life-threatening causes include conditions that may result in death or permanent disability within 24 hours if left untreated.
Common Causes
Common causes include:[1]
- Factor V Leiden
- Prothrombin gene mutation such as Prothrombin G20210A
- Protein C deficiency
- Protein S deficiency
- Antithrombin deficiency
- Medications such as oral contraceptives
Less Common Causes
Less common causes include:[1][2]
- Elevation in some coagulation factors such as VIII, IX and XI
- Dysfibrinogenemia
- Hyperhomocysteinemia and Methylenetetrahydrofolate mutation
- Plasminogen deficiency
- Elevated Lipoprotein(a)
Diagnosis
Shown below is an algorithm summarizing the diagnosis of [[disease name]] according the the [...] guidelines.
Treatment
Shown below is an algorithm summarizing the treatment of [[disease name]] according the the [...] guidelines.
Do's
- The content in this section is in bullet points.
Don'ts
- The content in this section is in bullet points.
References
- ↑ 1.0 1.1 Khan S, Dickerman JD (2006). "Hereditary thrombophilia". Thromb J. 4: 15. doi:10.1186/1477-9560-4-15. PMC 1592479. PMID 16968541.
- ↑ Rey E, Kahn SR, David M, Shrier I (2003). "Thrombophilic disorders and fetal loss: a meta-analysis". Lancet. 361 (9361): 901–8. doi:10.1016/S0140-6736(03)12771-7. PMID 12648968.